New Taxane Diterpenoids from Taiwanese Taxus sumatrana

• Published in: Chemical & Pharmaceutical Bulletin Vol. 51; no. 7; pp. 867 - 869
• Main Authors: Shen, Ya-Ching, Pan, Yu-Ling, Lo, Kuang-Liang, Wang, Shih-Sheng, Chang, Yao-To, Wang, Li-Tang, Lin, Yu-Chi
• Format: Journal Article
• Language: English; Japanese
• Published: TOKYO The Pharmaceutical Society of Japan 2003; Pharmaceutical Society of Japan; Pharmaceutical Soc Japan; Maruzen; Japan Science and Technology Agency
• Subjects: Biological and medical sciences; Bridged-Ring Compounds - chemistry; Bridged-Ring Compounds - isolation & purification; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Diterpenes - chemistry; Diterpenes - isolation & purification; General pharmacology; Life Sciences & Biomedicine; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Physical Sciences; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Leaves; Plant Stems; Science & Technology; Taiwan; tasumatrol; Taxaceae; taxane diterpenoid; Taxoids - chemistry; Taxoids - isolation & purification; Taxus; Taxus sumatrana; Asia; Taiwan; SEEDS; Taxus sumatrana; Taxaceae; BARK; TAXOIDS; ROOTS; MAIREI; YEW; tasumatrol; taxane diterpenoid; CUSPIDATA; Pentacyclic compound; Alcohol; Oxygen heterocycle; Stem; Medicinal plant; Taxane derivatives; Gymnospermae; Polyol; Acylate; Terpenoid; Taxus; Pharmacognosy; Lactone; Plant leaf; Tetracyclic compound; Plant origin; Diterpene; Isolation; Coniferales; Spermatophyta; Structural analysis
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.51.867

Two new taxane diterpenoids, tasumatrols A (1) and B (2), have been isolated from extracts of the leaves and twigs of Taiwanese Taxus sumatrana. Tasumatrol A is a rare 5/6/6 taxene system, having a novel γ-lactone at C-10 and C-19. The structures of compounds 1 and 2 were determined on the basis of two dimensional (2D)-NMR techniques, including correlation spectroscopy (COSY), 1H-detected heteronuclear multiple quantum coherence (HMQC) and heteronuclear multiple bond connectivity (HMBC) experiments.