The Role of Salicornia herbacea in Ovariectomy-Induced Oxidative Stress

Ovarian hormone deficiency increases the generation of reactive oxygen species. Their excess induces oxidative stress, which results in the cell damage or death. It causes the aging diseases—atherosclerosis, rheumatoid arthritis, osteoporosis, etc. Ovariectomized rats are used as oxidative stress mo...

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Published inBiological & Pharmaceutical Bulletin Vol. 29; no. 7; pp. 1305 - 1309
Main Authors Ha, Bae Jin, Lee, Sang Hun, Kim, Hee Jin, Lee, Jin Young
Format Journal Article
LanguageEnglish
Japanese
Published Japan The Pharmaceutical Society of Japan 2006
Pharmaceutical Society of Japan
Japan Science and Technology Agency
Subjects
Animals
antioxidant
Catalase - metabolism
Chenopodiaceae
Female
Free Radical Scavengers - metabolism
Liver - enzymology
Mitochondria, Liver - enzymology
Ovariectomy
oxidative stress
Oxidative Stress - drug effects
Oxidative Stress - physiology
Plant Extracts - pharmacology
Rats
Rats, Sprague-Dawley
Salicornia herbacea
Superoxide Dismutase - metabolism
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Summary:Ovarian hormone deficiency increases the generation of reactive oxygen species. Their excess induces oxidative stress, which results in the cell damage or death. It causes the aging diseases—atherosclerosis, rheumatoid arthritis, osteoporosis, etc. Ovariectomized rats are used as oxidative stress models. We verified the effects of ovariectomy-induced oxidative stress on free radical production as evaluated by DPPH elimination, lipoperoxidation evaluated by malondialdehyde levels, and antioxidant activation of superoxide dismutase, catalase, glutathione peroxidase, and estradiol in the liver and sera. Ovariectomized rats were given Salicornia herbacea (SH) intraperitoneally at the dose of 100 mg/kg daily for 2 months. Free radical-scavenging activity of SH was measured in comparison with that of L-ascorbic acid. The histopathology of liver tissue was also investigated. Antioxidative values in the ovariectomized group decreased, but those in the SH-treated group increased due to the free radical-scavenging activity of SH. Moreover, inflammation and cirrhosis in the liver tissue of SH-treated rats decreased significantly. These results suggest that SH may be a potential candidate for an antioxidative reagent.
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ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.29.1305