Dispositions of enrofloxacin and its major metabolite ciprofloxacin in Thai swamp buffaloes

• Published in: Journal of Veterinary Medical Science Vol. 78; no. 3; pp. 397 - 403
• Main Authors: RUENNARONG, Nitwarat, WONGPANIT, Kannika, SAKULTHAEW, Chainarong, GIORGI, Mario, KUMAGAI, Susumu, POAPOLATHEP, Amnart, POAPOLATHEP, Saranya
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.03.2016; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Administration, Intravenous; Animals; Anti-Bacterial Agents - pharmacokinetics; Buffaloes - metabolism; ciprofloxacin; Ciprofloxacin - administration & dosage; Ciprofloxacin - pharmacokinetics; Enrofloxacin; Female; Fluoroquinolones - administration & dosage; Fluoroquinolones - pharmacokinetics; Hypodermoclysis; pharmacokinetic; Pharmacology; Thai swamp buffalo; Thailand
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.15-0464

Given the limited information available in this species, the aim of this study was to investigate the pharmacokinetic characteristics of enrofloxacin (ER) and its major metabolite ciprofloxacin (CP) in buffaloes, Bubalus bubalis. ER was administered intravenously (i.v.) or subcutaneously (s.c.) to buffaloes at doses of 5.0 and 7.5 mg/kg BW, and plasma, urine and fecal samples were collected until 48 hr post-administration. The concentrations of ER and CP in the plasma, urine and feces were analyzed using high-performance liquid chromatography equipped with a fluorescence detector. The plasma concentrations of ER and CP could be determined up to 24 hr and 32 hr after i.v. and s.c. administrations at doses of 5.0 and 7.5 mg/kg BW, respectively. CP concentrations were always lower than those of parental drug. The s.c. bioavailability of ER was 52.36 ± 4.24% and 72.12 ± 5.39% at doses of 5.0 and 7.5 mg/kg BW, respectively. Both ER and CP were detectable in urine and feces up to 24 hr. ER and CP were mainly excreted via the urine. Based on the pharmacokinetic data and PK-PD indices, s.c. administration of ER at doses of 5.0 and 7.5 mg/kg BW might be appropriate for the treatment of susceptible bacterial diseases in Thai swamp buffaloes.