Avian and Human Influenza A Virus Receptors in Bovine Mammary Gland

• Published in: Emerging infectious diseases Vol. 30; no. 9; pp. 1907 - 1911
• Main Authors: Kristensen, Charlotte, Jensen, Henrik E., Trebbien, Ramona, Webby, Richard J., Larsen, Lars E.
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.09.2024; Centers for Disease Control and Prevention
• Subjects: Acids; Animals; Avian and Human Influenza A Virus Receptors in Bovine Mammary Gland; Avian flu; Birds - virology; Care and treatment; Cattle; Cattle Diseases - virology; Cell receptors; Dairy cattle; Diagnosis; Diseases; Dispatch; Female; Genetic aspects; Histochemistry; Histology; host tropism; Humans; Identification and classification; Infections; Influenza; influenza A virus; Influenza A Virus, H5N1 Subtype; Influenza in Birds - epidemiology; Influenza in Birds - virology; Influenza, Human - virology; Laboratories; Lectins; Mammary glands; Mammary Glands, Animal - virology; Medical examination; Milk - virology; Orthomyxoviridae Infections - veterinary; Orthomyxoviridae Infections - virology; Pathogenesis; receptor; Receptors, Cell Surface - metabolism; Receptors, Virus - metabolism; sialic acid; Viral infections; Viruses; Zoonoses; United States; United States > US; Texas; influenza; viruses; receptor; United States; sialic acid; cattle; host tropism; influenza A virus
• ISSN: 1080-6040; 1080-6059; 1080-6059
• DOI: 10.3201/eid3009.240696

An outbreak of influenza A (H5N1) virus was detected in dairy cows in the United States. We detected influenza A virus sialic acid -α2,3/α2,6-galactose host receptors in bovine mammary glands by lectin histochemistry. Our results provide a rationale for the high levels of H5N1 virus in milk from infected cows.