Phytoestrogens from Aspalathus linearis

From the leaves of Aspalathus linearis, 24 known compounds and a new one, aspalalinin (25), were isolated. The structures of the compounds were determined mainly based on spectral evidence. The absolute configuration of aspalalinin was presented on the basis of X-ray analysis. Each isolate was asses...

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Published inBiological & Pharmaceutical Bulletin Vol. 29; no. 6; pp. 1271 - 1274
Main Authors Shimamura, Naomi, Miyase, Toshio, Umehara, Kaoru, Warashina, Tsutomu, Fujii, Satoshi
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.06.2006
Pharmaceutical Society of Japan
Japan Science and Technology Agency
Subjects
Aspalathus - chemistry
Aspalathus linearis
Crystallography, X-Ray
dihydrochalcone
Enzyme-Linked Immunosorbent Assay
Estradiol - chemistry
Estradiol - pharmacology
Leguminosae
Molecular Structure
phytoestrogen
Phytoestrogens - chemistry
Phytoestrogens - isolation & purification
Phytoestrogens - pharmacology
Plant Leaves - chemistry
Structure-Activity Relationship
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Abstract From the leaves of Aspalathus linearis, 24 known compounds and a new one, aspalalinin (25), were isolated. The structures of the compounds were determined mainly based on spectral evidence. The absolute configuration of aspalalinin was presented on the basis of X-ray analysis. Each isolate was assessed for its estrogenic activity by an estrogen ELISA assay. Compounds 12, 15, and 24 showed the estrogenic activity.
AbstractList From the leaves of Aspalathus linearis, 24 known compounds and a new one, aspalalinin (25), were isolated. The structures of the compounds were determined mainly based on spectral evidence. The absolute configuration of aspalalinin was presented on the basis of X-ray analysis. Each isolate was assessed for its estrogenic activity by an estrogen ELISA assay. Compounds 12, 15, and 24 showed the estrogenic activity.
From the leaves of Aspalathus linearis, 24 known compounds and a new one, aspalalinin (25), were isolated. The structures of the compounds were determined nrainly based on spectral evidence. The absolute configuration of aspalalinin was presented on the basis of X-ray analysis. Each isolate was assessed for its estrogenic activity by an estrogen ELISA assay. Compounds 12, 15, and 24 showed the estrogenic activity. The sex hormone estrogens play various roles in both the male and fernale body. Estrogens are used in hormone replacement therapy (HRT) to prevent hot flashes and osteoporosis in postmenopausal women. 1, 2) Plant-derived phyto-estrogens also demonstrate estrogenic activity, and are of interest as a dietary potential alternative to the estrogens in HRT. 3) Aspalathus linearis (N. L. BURM. ) R. DAHLGR. is a leguminous shrub and grows in a mountainous area of South Africa.
Author Fujii, Satoshi
Shimamura, Naomi
Miyase, Toshio
Umehara, Kaoru
Warashina, Tsutomu
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  organization: School of Pharmaceutical Sciences, University of Shizuoka
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Snippet From the leaves of Aspalathus linearis, 24 known compounds and a new one, aspalalinin (25), were isolated. The structures of the compounds were determined...
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SubjectTerms Aspalathus - chemistry
Aspalathus linearis
Crystallography, X-Ray
dihydrochalcone
Enzyme-Linked Immunosorbent Assay
Estradiol - chemistry
Estradiol - pharmacology
Leguminosae
Molecular Structure
phytoestrogen
Phytoestrogens - chemistry
Phytoestrogens - isolation & purification
Phytoestrogens - pharmacology
Plant Leaves - chemistry
Structure-Activity Relationship
Title Phytoestrogens from Aspalathus linearis
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