Phytoestrogens from Aspalathus linearis

From the leaves of Aspalathus linearis, 24 known compounds and a new one, aspalalinin (25), were isolated. The structures of the compounds were determined mainly based on spectral evidence. The absolute configuration of aspalalinin was presented on the basis of X-ray analysis. Each isolate was asses...

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Bibliographic Details
Published inBiological & Pharmaceutical Bulletin Vol. 29; no. 6; pp. 1271 - 1274
Main Authors Shimamura, Naomi, Miyase, Toshio, Umehara, Kaoru, Warashina, Tsutomu, Fujii, Satoshi
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.06.2006
Pharmaceutical Society of Japan
Japan Science and Technology Agency
Subjects
Aspalathus - chemistry
Aspalathus linearis
Crystallography, X-Ray
dihydrochalcone
Enzyme-Linked Immunosorbent Assay
Estradiol - chemistry
Estradiol - pharmacology
Leguminosae
Molecular Structure
phytoestrogen
Phytoestrogens - chemistry
Phytoestrogens - isolation & purification
Phytoestrogens - pharmacology
Plant Leaves - chemistry
Structure-Activity Relationship
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Summary:From the leaves of Aspalathus linearis, 24 known compounds and a new one, aspalalinin (25), were isolated. The structures of the compounds were determined mainly based on spectral evidence. The absolute configuration of aspalalinin was presented on the basis of X-ray analysis. Each isolate was assessed for its estrogenic activity by an estrogen ELISA assay. Compounds 12, 15, and 24 showed the estrogenic activity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.29.1271