Clinicopathologic and Immunohistochemical Findings from Autopsy of Patient with COVID-19, Japan

• Published in: Emerging infectious diseases Vol. 26; no. 9; pp. 2157 - 2161
• Main Authors: Adachi, Takuya, Chong, Ja-Mun, Nakajima, Noriko, Sano, Masahiro, Yamazaki, Jun, Miyamoto, Ippei, Nishioka, Haruka, Akita, Hidetaka, Sato, Yuko, Kataoka, Michiyo, Katano, Harutaka, Tobiume, Minoru, Sekizuka, Tsuyoshi, Itokawa, Kentaro, Kuroda, Makoto, Suzuki, Tadaki
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.09.2020; Centers for Disease Control and Prevention
• Subjects: Aged, 80 and over; Alveolar Epithelial Cells - pathology; Alveolar Epithelial Cells - virology; Antigens; Autopsy; Betacoronavirus; Clinicopathologic and Immunohistochemical Findings from Autopsy of Patient with COVID-19, Japan; Coronavirus Infections - pathology; Coronavirus Infections - virology; Coronaviruses; COVID-19; cruise; Dehydrogenases; diffuse alveolar damage; Disease transmission; Dispatch; Dyspnea; Epidemics; Female; Grants; Health aspects; Hospitals; Humans; Illnesses; Immunohistochemistry; Japan; Laboratories; Lung - pathology; Lung - virology; Lungs; Medical research; Membranes; Methicillin; Mutation; Pandemics; Pathology; Pneumonia, Viral - pathology; Pneumonia, Viral - virology; R&D; Research & development; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Sulbactam; Throat; Tropical diseases; Japan; China; viruses; diffuse alveolar damage; next-generation sequencing; Japan; zoonoses; respiratory infections; COVID-19; SARS-CoV-2; severe acute respiratory syndrome coronavirus 2; cruise; electron microscopy; coronavirus disease; immunohistochemistry; autopsy

An autopsy of a patient in Japan with coronavirus disease indicated pneumonia lung pathology, manifested as diffuse alveolar damage. We detected severe acute respiratory syndrome coronavirus 2 antigen in alveolar epithelial cells and macrophages. Coronavirus disease is essentially a lower respirator...