Clinicopathologic and Immunohistochemical Findings from Autopsy of Patient with COVID-19, Japan

An autopsy of a patient in Japan with coronavirus disease indicated pneumonia lung pathology, manifested as diffuse alveolar damage. We detected severe acute respiratory syndrome coronavirus 2 antigen in alveolar epithelial cells and macrophages. Coronavirus disease is essentially a lower respirator...

Full description

Saved in:
Bibliographic Details
Published inEmerging infectious diseases Vol. 26; no. 9; pp. 2157 - 2161
Main Authors Adachi, Takuya, Chong, Ja-Mun, Nakajima, Noriko, Sano, Masahiro, Yamazaki, Jun, Miyamoto, Ippei, Nishioka, Haruka, Akita, Hidetaka, Sato, Yuko, Kataoka, Michiyo, Katano, Harutaka, Tobiume, Minoru, Sekizuka, Tsuyoshi, Itokawa, Kentaro, Kuroda, Makoto, Suzuki, Tadaki
Format Journal Article
LanguageEnglish
Published United States U.S. National Center for Infectious Diseases 01.09.2020
Centers for Disease Control and Prevention
Subjects
Aged, 80 and over
Alveolar Epithelial Cells - pathology
Alveolar Epithelial Cells - virology
Antigens
Autopsy
Betacoronavirus
Clinicopathologic and Immunohistochemical Findings from Autopsy of Patient with COVID-19, Japan
Coronavirus Infections - pathology
Coronavirus Infections - virology
Coronaviruses
COVID-19
cruise
Dehydrogenases
diffuse alveolar damage
Disease transmission
Dispatch
Dyspnea
Epidemics
Female
Grants
Health aspects
Hospitals
Humans
Illnesses
Immunohistochemistry
Japan
Laboratories
Lung - pathology
Lung - virology
Lungs
Medical research
Membranes
Methicillin
Mutation
Pandemics
Pathology
Pneumonia, Viral - pathology
Pneumonia, Viral - virology
R&D
Research & development
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Sulbactam
Throat
Tropical diseases
Japan
China
viruses
diffuse alveolar damage
next-generation sequencing
Japan
zoonoses
respiratory infections
COVID-19
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2
cruise
electron microscopy
coronavirus disease
immunohistochemistry
autopsy
Online AccessGet full text

Cover

More Information
Summary:An autopsy of a patient in Japan with coronavirus disease indicated pneumonia lung pathology, manifested as diffuse alveolar damage. We detected severe acute respiratory syndrome coronavirus 2 antigen in alveolar epithelial cells and macrophages. Coronavirus disease is essentially a lower respiratory tract disease characterized by direct viral injury of alveolar epithelial cells.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Case Study-2
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid2609.201353