Clinicopathologic and Immunohistochemical Findings from Autopsy of Patient with COVID-19, Japan
An autopsy of a patient in Japan with coronavirus disease indicated pneumonia lung pathology, manifested as diffuse alveolar damage. We detected severe acute respiratory syndrome coronavirus 2 antigen in alveolar epithelial cells and macrophages. Coronavirus disease is essentially a lower respirator...
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| Published in | Emerging infectious diseases Vol. 26; no. 9; pp. 2157 - 2161 |
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| Main Authors | , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
U.S. National Center for Infectious Diseases
01.09.2020
Centers for Disease Control and Prevention |
| Subjects | |
| Online Access | Get full text |
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| Abstract | An autopsy of a patient in Japan with coronavirus disease indicated pneumonia lung pathology, manifested as diffuse alveolar damage. We detected severe acute respiratory syndrome coronavirus 2 antigen in alveolar epithelial cells and macrophages. Coronavirus disease is essentially a lower respiratory tract disease characterized by direct viral injury of alveolar epithelial cells. |
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| AbstractList | An autopsy of a patient in Japan with coronavirus disease indicated pneumonia lung pathology, manifested as diffuse alveolar damage. We detected severe acute respiratory syndrome coronavirus 2 antigen in alveolar epithelial cells and macrophages. Coronavirus disease is essentially a lower respiratory tract disease characterized by direct viral injury of alveolar epithelial cells. An autopsy of a patient in Japan with coronavirus disease indicated pneumonia lung pathology, manifested as diffuse alveolar damage. We detected severe acute respiratory syndrome coronavirus 2 antigen in alveolar epithelial cells and macrophages. Coronavirus disease is essentially a lower respiratory tract disease characterized by direct viral injury of alveolar epithelial cells.An autopsy of a patient in Japan with coronavirus disease indicated pneumonia lung pathology, manifested as diffuse alveolar damage. We detected severe acute respiratory syndrome coronavirus 2 antigen in alveolar epithelial cells and macrophages. Coronavirus disease is essentially a lower respiratory tract disease characterized by direct viral injury of alveolar epithelial cells. |
| Audience | Professional Academic |
| Author | Sato, Yuko Akita, Hidetaka Chong, Ja-Mun Kuroda, Makoto Suzuki, Tadaki Nishioka, Haruka Kataoka, Michiyo Katano, Harutaka Tobiume, Minoru Yamazaki, Jun Nakajima, Noriko Miyamoto, Ippei Sano, Masahiro Itokawa, Kentaro Sekizuka, Tsuyoshi Adachi, Takuya |
| Author_xml | – sequence: 1 givenname: Takuya surname: Adachi fullname: Adachi, Takuya – sequence: 2 givenname: Ja-Mun surname: Chong fullname: Chong, Ja-Mun – sequence: 3 givenname: Noriko surname: Nakajima fullname: Nakajima, Noriko – sequence: 4 givenname: Masahiro surname: Sano fullname: Sano, Masahiro – sequence: 5 givenname: Jun surname: Yamazaki fullname: Yamazaki, Jun – sequence: 6 givenname: Ippei surname: Miyamoto fullname: Miyamoto, Ippei – sequence: 7 givenname: Haruka surname: Nishioka fullname: Nishioka, Haruka – sequence: 8 givenname: Hidetaka surname: Akita fullname: Akita, Hidetaka – sequence: 9 givenname: Yuko surname: Sato fullname: Sato, Yuko – sequence: 10 givenname: Michiyo surname: Kataoka fullname: Kataoka, Michiyo – sequence: 11 givenname: Harutaka surname: Katano fullname: Katano, Harutaka – sequence: 12 givenname: Minoru surname: Tobiume fullname: Tobiume, Minoru – sequence: 13 givenname: Tsuyoshi surname: Sekizuka fullname: Sekizuka, Tsuyoshi – sequence: 14 givenname: Kentaro surname: Itokawa fullname: Itokawa, Kentaro – sequence: 15 givenname: Makoto surname: Kuroda fullname: Kuroda, Makoto – sequence: 16 givenname: Tadaki surname: Suzuki fullname: Suzuki, Tadaki |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32412897$$D View this record in MEDLINE/PubMed |
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| Copyright | COPYRIGHT 2020 U.S. National Center for Infectious Diseases Published 2020. This article is a U.S. Government work and is in the public domain in the USA. |
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| Keywords | viruses diffuse alveolar damage next-generation sequencing Japan zoonoses respiratory infections COVID-19 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 cruise electron microscopy coronavirus disease immunohistochemistry autopsy |
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| SubjectTerms | Aged, 80 and over Alveolar Epithelial Cells - pathology Alveolar Epithelial Cells - virology Antigens Autopsy Betacoronavirus Clinicopathologic and Immunohistochemical Findings from Autopsy of Patient with COVID-19, Japan Coronavirus Infections - pathology Coronavirus Infections - virology Coronaviruses COVID-19 cruise Dehydrogenases diffuse alveolar damage Disease transmission Dispatch Dyspnea Epidemics Female Grants Health aspects Hospitals Humans Illnesses Immunohistochemistry Japan Laboratories Lung - pathology Lung - virology Lungs Medical research Membranes Methicillin Mutation Pandemics Pathology Pneumonia, Viral - pathology Pneumonia, Viral - virology R&D Research & development SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Sulbactam Throat Tropical diseases |
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| Title | Clinicopathologic and Immunohistochemical Findings from Autopsy of Patient with COVID-19, Japan |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/32412897 https://www.proquest.com/docview/2466921024 https://www.proquest.com/docview/2404043054 https://pubmed.ncbi.nlm.nih.gov/PMC7454070 https://doaj.org/article/3965b17ad2964cbab305b63747603b6c |
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