SARS-CoV-2 Neutralization Resistance Mutations in Patient with HIV/AIDS, California, USA

• Published in: Emerging infectious diseases Vol. 27; no. 10; pp. 2720 - 2723
• Main Authors: Hoffman, Seth A., Costales, Cristina, Sahoo, Malaya K., Palanisamy, Srikanth, Yamamoto, Fumiko, Huang, ChunHong, Verghese, Michelle, Solis, Daniel A., Sibai, Mamdouh, Subramanian, Aruna, Tompkins, Lucy S., Grant, Philip, Shafer, Robert W., Pinsky, Benjamin A.
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.10.2021; Centers for Disease Control and Prevention
• Subjects: Acquired immune deficiency syndrome; Acquired Immunodeficiency Syndrome; AIDS; Coronaviruses; COVID-19; Gene mutations; Genetic aspects; Health aspects; HIV; HIV patients; HIV/AIDS; Human immunodeficiency virus; Humans; immunocompromised; Medical examination; Mutation; Protein Binding; Research Letter; respiratory infections; SARS-CoV-2; SARS-CoV-2 Neutralization Resistance Mutations in Patient with HIV/AIDS, California, USA; Spike Glycoprotein, Coronavirus - genetics; viral evolution; United States; United Kingdom > UK; United States > US; California; HIV/AIDS; viruses; United States; zoonoses; coronaviruses; California; immunocompromised; respiratory infections; COVID-19; SARS-CoV-2; antimicrobial resistance; severe acute respiratory syndrome coronavirus 2; viral evolution; 2019 novel coronavirus disease; coronavirus disease
• ISSN: 1080-6040; 1080-6059; 1080-6059
• DOI: 10.3201/eid2710.211461

We report persistent severe acute respiratory syndrome coronavirus 2 infection in a patient with HIV/AIDS; the virus developed spike N terminal domain and receptor binding domain neutralization resistance mutations. Our findings suggest that immunocompromised patients can harbor emerging variants of severe acute respiratory syndrome coronavirus 2.