Global Trends in Norovirus Genotype Distribution among Children with Acute Gastroenteritis

• Published in: Emerging infectious diseases Vol. 27; no. 5; pp. 1438 - 1445
• Main Authors: Cannon, Jennifer L., Bonifacio, Joseph, Bucardo, Filemon, Buesa, Javier, Bruggink, Leesa, Chan, Martin Chi-Wai, Fumian, Tulio M., Giri, Sidhartha, Gonzalez, Mark D., Hewitt, Joanne, Lin, Jih-Hui, Mans, Janet, Muñoz, Christian, Pan, Chao-Yang, Pang, Xiao-Li, Pietsch, Corinna, Rahman, Mustafiz, Sakon, Naomi, Selvarangan, Rangaraj, Browne, Hannah, Barclay, Leslie, Vinjé, Jan
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.05.2021; Centers for Disease Control and Prevention
• Subjects: Age groups; Asymptomatic; capsids; children; Communicable diseases in children; Distribution; Gastroenteritis; Genetic aspects; Genotype & phenotype; Genotypes; Global Trends in Norovirus Genotype Distribution among Children with Acute Gastroenteritis; Identification and classification; Illnesses; Infections; International aspects; Laboratories; Norovirus; Pediatric research; Pediatrics; RNA virus infections; Statistics; Surveillance; Trends; Vaccines; Southern Hemisphere; United States > US; Philippines; Spain; New Zealand; Nicaragua; Northern Hemisphere; Asia; China; Hong Kong China; Australia; Chile; Germany; viruses; vaccines; polymerase; genotypes; P-types; food safety; dual typing; children; gastroenteritis; norovirus; capsids; enteric infections; surveillance; acute gastroenteritis; NoroSurv
• ISSN: 1080-6040; 1080-6059; 1080-6059
• DOI: 10.3201/eid2705.204756

Noroviruses are a leading cause of acute gastroenteritis (AGE) among adults and children worldwide. NoroSurv is a global network for norovirus strain surveillance among children <5 years of age with AGE. Participants in 16 countries across 6 continents used standardized protocols for dual typing (genotype and polymerase type) and uploaded 1,325 dual-typed sequences to the NoroSurv web portal during 2016-2020. More than 50% of submitted sequences were GII.4 Sydney[P16] or GII.4 Sydney[P31] strains. Other common strains included GII.2[P16], GII.3[P12], GII.6[P7], and GI.3[P3] viruses. In total, 22 genotypes and 36 dual types, including GII.3 and GII.20 viruses with rarely reported polymerase types, were detected, reflecting high strain diversity. Surveillance data captured in NoroSurv enables the monitoring of trends in norovirus strains associated childhood AGE throughout the world on a near real-time basis.