New Flavan and Benzil Isolated from Fissistigma latifolium

• Published in: Chemical & pharmaceutical bulletin Vol. 60; no. 2; pp. 280 - 282
• Main Authors: Lan, Yu-Hsuan, Peng, Yi-Ting, Thang, Tran-Dinh, Hwang, Tsong-Long, Dai, Do-Ngoc, Leu, Yann-Lii, Lai, Wan-Chun, Wu, Yang-Chang
• Format: Journal Article
• Language: English; Japanese
• Published: TOKYO The Pharmaceutical Society of Japan 2012; Pharmaceutical Society of Japan; Pharmaceutical Soc Japan; Japan Science and Technology Agency
• Subjects: Annonaceae; Annonaceae - chemistry; benzil; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Enzyme Inhibitors - pharmacology; Fissistigma latifolium; flavan; Flavonoids - chemistry; Flavonoids - pharmacology; Humans; Inhibitory Concentration 50; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Molecular Structure; Neutrophils - drug effects; Neutrophils - immunology; Pharmacology & Pharmacy; Phenylglyoxal - analogs & derivatives; Phenylglyoxal - chemistry; Phenylglyoxal - isolation & purification; Phenylglyoxal - pharmacology; Physical Sciences; Science & Technology; Superoxides - metabolism; flavan; BALANSAE; OLDHAMII; FLAVONOIDS; Annonaceae; benzil; Fissistigma latifolium; ALKALOIDS; GLAUCESCENS
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.60.280

Further investigation of the methanolic extract of Fissistigma latifolium resulted in two new compounds whose structures were assigned as 2,5,6,7-tetramethoxyflavan (1) and 2′-hydroxy-4′,5′,6′-trimethoxybenzil (2). These two compounds were determined on the basis of chemical and spectroscopic evidences. Compound 2 is the first report of benzil from Fissistigma species. 2,5,6,7-Tetramethoxyflavan (1) showed a potent inhibitory effect on superoxide anion production in formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)/cytochalasin B (CB)-activated human neutrophils.