A novel bioactive nerve conduit for the repair of peripheral nerve injury

• Published in: Neural regeneration research Vol. 11; no. 1; pp. 150 - 155
• Main Authors: Li, Bin-bin, Yin, Yi-xia, Yan, Qiong-jiao, Wang, Xin-yu, Li, Shi-pu
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer - Medknow Publications 2016; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, Hubei Province, China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Acids; Biocompatibility; Care and treatment; Composite materials; Cybernetics; Cytokines; Diagnosis; Laboratory animals; Morphology; nerve regeneration; polylactic acid; poly{(lactic acid)-co-[(glycolic acid)-alt-(L-lysine)]}; β-tricalcium phosphate; nerve conduit; nerve fiber; neural regeneration; Neurotrophins; PDLLA; Peptides; Peripheral nervous system diseases; Risk factors; β-磷酸三钙; 修复; 周围神经损伤; 导管; 生物活性; 神经再生; 神经营养因子; United States > US; China; nerve regeneration; polylactic acid; nerve conduit; β-tricalcium phosphate; neural regeneration; nerve fiber; poly{(lactic acid)-co-[(glycolic acid)-alt-(L-lysine)]}; polylactic acid; nerve regeneration

The use of a nerve conduit provides an opportunity to regulate cytokines, growth factors and neurotrophins in peripheral nerve regeneration and avoid autograft defects. We constructed a poly-D-L-lactide（PDLLA）-based nerve conduit that was modified using poly{（lactic acid）-co-[（glycolic acid）-alt-（L-...