A novel bioactive nerve conduit for the repair of peripheral nerve injury

• Published in: Neural regeneration research Vol. 11; no. 1; pp. 150 - 155
• Main Authors: Li, Bin-bin, Yin, Yi-xia, Yan, Qiong-jiao, Wang, Xin-yu, Li, Shi-pu
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer - Medknow Publications 2016; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, Hubei Province, China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Acids; Biocompatibility; Care and treatment; Composite materials; Cybernetics; Cytokines; Diagnosis; Laboratory animals; Morphology; nerve regeneration; polylactic acid; poly{(lactic acid)-co-[(glycolic acid)-alt-(L-lysine)]}; β-tricalcium phosphate; nerve conduit; nerve fiber; neural regeneration; Neurotrophins; PDLLA; Peptides; Peripheral nervous system diseases; Risk factors; β-磷酸三钙; 修复; 周围神经损伤; 导管; 生物活性; 神经再生; 神经营养因子; United States > US; China; nerve regeneration; polylactic acid; nerve conduit; β-tricalcium phosphate; neural regeneration; nerve fiber; poly{(lactic acid)-co-[(glycolic acid)-alt-(L-lysine)]}; polylactic acid; nerve regeneration
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.175062

The use of a nerve conduit provides an opportunity to regulate cytokines, growth factors and neurotrophins in peripheral nerve regeneration and avoid autograft defects. We constructed a poly-D-L-lactide（PDLLA）-based nerve conduit that was modified using poly{（lactic acid）-co-[（glycolic acid）-alt-（L-lysine）]} and β-tricalcium phosphate. The effectiveness of this bioactive PDLLA-based nerve conduit was compared to that of PDLLA-only conduit in the nerve regeneration following a 10-mm sciatic nerve injury in rats. We observed the nerve morphology in the early period of regeneration, 35 days post injury, using hematoxylin-eosin and methylene blue staining. Compared with the PDLLA conduit, the nerve fibers in the PDLLA-based bioactive nerve conduit were thicker and more regular in size. Muscle fibers in the soleus muscle had greater diameters in the PDLLA bioactive group than in the PDLLA only group. The PDLLA-based bioactive nerve conduit is a promising strategy for repair after sciatic nerve injury.