High Levels of Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Acute Stroke: An Age- and Sex-Matched Cross-Sectional Study

• Published in: Journal of Atherosclerosis and Thrombosis Vol. 23; no. 10; pp. 1222 - 1226
• Main Authors: Yokota, Chiaki, Sawamura, Tatsuya, Watanabe, Makoto, Kokubo, Yoshihiro, Fujita, Yoshiko, Kakino, Akemi, Nakai, Michikazu, Toyoda, Kazunori, Miyamoto, Yoshihiro, Minematsu, Kazuo
• Format: Journal Article
• Language: English
• Published: Japan Japan Atherosclerosis Society 01.01.2016
• Subjects: Adult; Age Factors; Aged; Atherosclerosis; Atherosclerosis - blood; Atherosclerosis - diagnosis; Biomarker; Biomarkers - blood; Case-Control Studies; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Original; Prognosis; Scavenger Receptors, Class E - blood; Sex Factors; Stroke; Stroke - blood; Stroke - diagnosis
• ISSN: 1340-3478; 1880-3873; 1880-3873
• DOI: 10.5551/jat.32466

Aim: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is known to be a key molecule in the pathogenesis of atherosclerosis. Although high levels of serum soluble LOX-1 (sLOX-1) were demonstrated in patients with acute coronary syndrome, there are no reports about acute stroke patients. The aim of the present study was to evaluate the levels of sLOX-1 in acute stroke patients according to different stroke subtypes.Methods: We enrolled a total of 377 patients with a stroke (men/women: 251/126; age: 40–79 years), 250 with ischemic stroke and 127 with intracerebral hemorrhage (ICH). Patients were admitted to our hospital within 3 days after the onset of stroke. As controls, we randomly selected age- and sex-matched subjects without a past history of cardiovascular disease according to stroke subtype from the community-based cohort of the Suita study. Serum LOX-1 levels were compared between stroke patients and healthy controls according to stroke subtype.Results: Median values of serum sLOX-1 in stroke patients were significantly higher than those in controls (526 vs. 486 ng/L in ischemic stroke and 720 vs. 513 ng/L in ICH, respectively). Among subtypes of ischemic stroke, median sLOX-1 levels in atherothrombotic brain infarction (641 ng/L) only were significantly higher than those in controls (496 ng/L). Ischemic stroke [odds ratio (OR), 3.80; 95% confidence interval (CI), 1.86–7.74] and ICH (OR, 5.97; 95% CI, 2.13–16.77) were independently associated with high levels of sLOX-1 by multivariate logistic regression analysis.Conclusions: Higher levels of sLOX-1 were observed in patients with acute stoke than in controls. High levels of sLOX-1 can be useful as biomarker for acute stroke.