Preventive Effect of Chlorogenic Acid on Lens Opacity and Cytotoxicity in Human Lens Epithelial Cells

The present study reveals the pharmacological effect of chlorogenic acid, a major phenolic compound in plants, food, and coffee, on diabetic cataracts. Chlorogenic acid examined the inhibitory effects upon rat lens aldose reductase (AR) activity and xylose-induced rat lens opacity. The effect of chl...

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Bibliographic Details
Published inBiological & Pharmaceutical Bulletin Vol. 34; no. 6; pp. 925 - 928
Main Authors Kim, Young Sook, Kim, Nan Hee, Lee, Yun Mi, Kim, Jin Sook
Format Journal Article
LanguageEnglish
Japanese
Published Japan The Pharmaceutical Society of Japan 2011
Pharmaceutical Society of Japan
Japan Science and Technology Agency
Subjects
Aldehyde Reductase - antagonists & inhibitors
aldose reductase
Animals
Antioxidants - pharmacology
Cataract - chemically induced
Cataract - etiology
Cataract - prevention & control
Cell Line
Cell Survival - drug effects
chlorogenic acid
Chlorogenic Acid - pharmacology
cytotoxicity
Diabetes Complications - prevention & control
Enzyme Inhibitors - pharmacology
Epithelial Cells - drug effects
human lens epithelial cell
Humans
Hyperglycemia - physiopathology
lens opacity
Lens, Crystalline - drug effects
Lens, Crystalline - pathology
Organ Culture Techniques
Osmolar Concentration
Rats
Rats, Sprague-Dawley
Xylose - toxicity
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Summary:The present study reveals the pharmacological effect of chlorogenic acid, a major phenolic compound in plants, food, and coffee, on diabetic cataracts. Chlorogenic acid examined the inhibitory effects upon rat lens aldose reductase (AR) activity and xylose-induced rat lens opacity. The effect of chlorogenic acid on high glucose-induced cytotoxicity in lens epithelial cells was also examined. Chlorogenic acid showed potential inhibitory activity against rat lens AR, with an IC50 value of 0.95 μM. The xylose-induced opacity of lenses was significantly improved after treatment with chlorogenic acid in a dose-dependent manner. Chlorogenic acid prevented high glucose-induced cytotoxicity in human lens epithelial (HLE-B3) cells in a dose-dependent manner. These results suggest that chlorogenic acid may provide a potential therapeutic approach for prevention of diabetic complications, such as cataracts.
Bibliography:ObjectType-Article-1
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ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.34.925