Axial length and cone density as assessed with adaptive optics in myopia

• Published in: Indian journal of ophthalmology Vol. 63; no. 5; pp. 423 - 426
• Main Authors: Dabir, Supriya, Mangalesh, Shwetha, Schouten, Jan, Berendschot, Tos, Kurian, Mathew, Kumar, Anupama, Yadav, Naresh, Shetty, Rohit
• Format: Journal Article
• Language: English
• Published: India Medknow Publications 01.05.2015; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Adaptive optics; Adult; Age-related macular degeneration; axial length; Axial Length, Eye - pathology; Cell Count; Central reading center; Choroid; Choroidal imaging; Choroidal neovascularization; choroidal thickness; Community; Computer industry; cone density; Cystoid macular edema; dexamethasone implant; Diagnosis; digital imaging; en-face optical coherence tomography; enhanced depth imaging technique; external limiting membrane; Female; Fovea Centralis - pathology; Fundus autofluorescence; Humans; idiopathic juxtafoveal telangiectasis; juxtafoveal retinal telangiectasia; Karnataka Internet-assisted Diagnosis of Retinopathy of Prematurity; lipofuscin; lutein; macular edema; macular pigment; macular telangiectasia; Male; Mathematical models; Medical imaging; Microscope-integrated optical coherence tomography; Myopia; Myopia - pathology; Müller cells; optical coherence tomography; Optics and Photonics; Ozurdex; parafoveal telangiectasis; Patients; perifoveal telangiectasis; Photoreceptors; polypoidal choroidal vasculopathy; randomized controlled trial; RESCAN; Retina; retinal angiomatous proliferation; Retinal Cone Photoreceptor Cells - pathology; retinal dystrophies; retinal imaging; retinal telangiectasis; retinopathy of prematurity; serous retinal detachment; spectral domain optical coherence tomography; standard operating procedure; Studies; subretinal neovascularization; swept source optical coherence tomography; Symposium - Retinochoroidal Imaging; telemedicine; Tomography, Optical Coherence - instrumentation; universal screening; uveitis; vitreoretinal surgery; Young Adult; zeaxanthin; United States; myopia; Adaptive optics; axial length; cone density
• ISSN: 0301-4738; 1998-3689; 1998-3689
• DOI: 10.4103/0301-4738.159876

Aim: To assess the variations in cone mosaic in myopia and its correlation with axial length (AL). Subjects and Methods: Twenty-five healthy myopic volunteers underwent assessment of photoreceptors using adaptive optics retinal camera at 2° and 3° from the foveal center in four quadrants superior, inferior, temporal and nasal. Data was analyzed using SPSS version 17 (IBM). Multivariable regression analysis was conducted to study the relation between cone density and AL, quadrant around the fovea and eccentricity from the fovea. Results: The mean cone density was significantly lower as the eccentricity increased from 2° from the fovea to 3° (18,560 ± 5455-16,404 ± 4494/mm 2 respectively). There was also a statistically significant difference between four quadrants around the fovea. The correlation of cone density and spacing with AL showed that there was a significant inverse relation of AL with the cone density. Conclusion: In myopic patients with good visual acuity cone density around the fovea depends on the quadrant, distance from the fovea as well as the AL. The strength of the relation of AL with cone density depends on the quadrant and distance.