Food-Dependent Exercise-Induced Anaphylaxis—Importance of Omega-5 Gliadin and HMW-Glutenin as Causative Antigens for Wheat-Dependent Exercise-Induced Anaphylaxis

Food-dependent exercise-induced anaphylaxis (FDEIA) is a special form of food allergy where a food-intake alone does not induce any symptoms. However, allergic symptoms are elicited when triggering factors such as exercise or aspirin-intake are added after ingestion of the causative food. The most f...

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Published inAllergology International Vol. 58; no. 4; pp. 493 - 498
Main Authors Morita, Eishin, Matsuo, Hiroaki, Chinuki, Yuko, Takahashi, Hitoshi, Dahlström, Jörgen, AkiraTanaka
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 2009
JAPANESE SOCIETY OF ALLERGOLOGY
Elsevier
Subjects
allergen
Allergens - immunology
anaphylaxis
Anaphylaxis - complications
Anaphylaxis - diagnosis
Anaphylaxis - immunology
Antigens, Plant - immunology
Asthma, Exercise-Induced - complications
Asthma, Exercise-Induced - diagnosis
Asthma, Exercise-Induced - immunology
exercise
Food - adverse effects
Gastrointestinal Tract - metabolism
gliadin
Gliadin - immunology
Glutens - immunology
Humans
Immunoglobulin E - metabolism
Immunologic Tests
Triticum aestivum
wheat
Wheat Hypersensitivity - complications
Wheat Hypersensitivity - diagnosis
Wheat Hypersensitivity - immunology
allergen
exercise
anaphylaxis
wheat
gliadin
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Summary:Food-dependent exercise-induced anaphylaxis (FDEIA) is a special form of food allergy where a food-intake alone does not induce any symptoms. However, allergic symptoms are elicited when triggering factors such as exercise or aspirin-intake are added after ingestion of the causative food. The most frequent causative foodstuff in Japan is wheat. The triggering factors, both exercise and aspirin-intake, facilitate allergen absorption from the gastrointestinal tract, resulting in allergic symptoms in the patients with wheat-dependent exercise-induced anaphylaxis (WDEIA). Analysis using purified wheat proteins revealed that approximately 80% of the patients with WDEIA have IgE reacting to omega-5 gliadin and the remaining of the patients to high molecular weight glutenin (HMW-glutenin). Simultaneous measurement of specific IgE to omega-5 gliadin and HMW-glutenin was found to be highly useful in diagnosing WDEIA compared with the routine diagnostic system for wheat.
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ISSN:1323-8930
1440-1592
DOI:10.2332/allergolint.09-RAI-0125