Mechanical properties of nerve roots and rami radiculares isolated from fresh pig spinal cords

• Published in: Neural regeneration research Vol. 10; no. 11; pp. 1869 - 1873
• Main Authors: Nishida, Norihiro, Kanchiku, Tsukasa, Ohgi, Junji, Ichihara, Kazuhiko, Chen, Xian, Taguchi, Toshihiko
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.11.2015; Medknow Publications & Media Pvt. Ltd; Department of Orthopedic Surgery, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan%Faculty of Engineering, Yamaguchi University, Yamaguchi, Japan%Non-Profit Organization Corporation, Japan Orthopedic Biomechanics Institute, Yamaguchi, Japan%Faculties of Engineering, Yamaguchi University, Yamaguchi, Japan; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Experiments; Hogs; Mechanical properties; Morphology; nerve regeneration; cauda equina syndrome; monoaxial tensile tests; radiculopathy; strength characteristics; stress-strain relationship; lumbar spinal canal stenosis; paralysis; spinal cord; neural degeneration; Personal computers; Spinal cord; Spinal nerves; Tensile strength; Trauma; Tumor necrosis factor-TNF; 分离; 应力-应变关系; 应力松弛试验; 强度特性; 新鲜; 机械性能; 脊神经; 脊髓; United States > US; Japan; monoaxial tensile tests; neural degeneration; strength characteristics; lumbar spinal canal stenosis; paralysis; nerve regeneration; radiculopathy; stress-strain relationship; spinal cord; cauda equina syndrome
• DOI: 10.4103/1673-5374.170319
• ISSN: 1673-5374

No reports have described experiments designed to determine the strength characteristics of spinal nerve roots and rami radiculares for the purpose of explaining the complexity of symptoms of medullary cone lesions and cauda equina syndrome. In this study, to explain the pathogenesis of cauda equina syndrome, monoaxial tensile tests were performed to determine the strength characteristics of spinal nerve roots and rami radiculares, and analysis was conducted to evaluate the stress-strain relationship and strength characteristics. Using the same tensile test device, the nerve root and ramus radiculares isolated from the spinal cords of pigs were subjected to the tensile test and stress relaxation test at load strain rates of 0.1, 1, 10, and 100 s-1 under identical settings. The tensile strength of the nerve root was not rate dependent, while the ramus radiculares tensile strength tended to decrease as the strain rate increased. These findings provide important insights into cauda equina symptoms, radiculopathy, and clinical symptoms of the medullary cone.