Microbiome metabolomics reveals new drivers of human liver steatosis

An integrative multiomics approach in nondiabetic obese women identifies phenylacetate as a microbial metabolite contributing to the accumulation of lipids in the liver and hence to nonalcoholic steatohepatitis.

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Bibliographic Details
Published inNature medicine Vol. 24; no. 7; pp. 906 - 907
Main Authors Delzenne, Nathalie M., Bindels, Laure B.
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.07.2018
Nature Publishing Group
Subjects
631/326/2565/2134
631/443/319/320
692/699/1503/1607/2750
Amino acids
Biomedical and Life Sciences
Biomedicine
Cancer Research
Carcinoma
Dehydrogenases
Development and progression
Fatty liver
Feces
Gene expression
Genetic aspects
Health aspects
Hepatocellular carcinoma
Infectious Diseases
Lipid metabolism
Lipids
Liver
Liver diseases
Metabolic Diseases
Metabolism
Metabolites
Metabolomics
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Molecular Medicine
Motor vehicle drivers
Neurosciences
News & Views
news-and-views
Nutrition
Nutrition research
Obesity
Overweight persons
Plasma
Steatosis
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Summary:An integrative multiomics approach in nondiabetic obese women identifies phenylacetate as a microbial metabolite contributing to the accumulation of lipids in the liver and hence to nonalcoholic steatohepatitis.
Bibliography:ObjectType-Article-2
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ISSN:1078-8956
1546-170X
DOI:10.1038/s41591-018-0126-3