Cytotoxic and Antimalarial Prenylated Xanthones from Cratoxylum cochinchinense

• Published in: Chemical & Pharmaceutical Bulletin Vol. 54; no. 5; pp. 745 - 747
• Main Authors: Laphookhieo, Surat, Syers, John Keith, Kiattansakul, Rattana, Chantrapromma, Kan
• Format: Journal Article
• Language: English
• Published: TOKYO The Pharmaceutical Society of Japan 2006; Pharmaceutical Society of Japan; Pharmaceutical Soc Japan; Japan Science and Technology Agency
• Subjects: 5-O-methylcelebixanthone; Animals; antimalarial activity; Antimalarials - chemistry; Antimalarials - isolation & purification; Antimalarials - pharmacology; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Cell Line, Tumor; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Clusiaceae - chemistry; Colorimetry; Cratoxylum cochinchinense; cytotoxic activity; Humans; KB Cells; Life Sciences & Biomedicine; Pharmacology & Pharmacy; Physical Sciences; Plant Roots - chemistry; Plasmodium falciparum - drug effects; Science & Technology; Spectrometry, Mass, Electrospray Ionization; Xanthones - chemistry; Xanthones - isolation & purification; Xanthones - pharmacology; Cratoxylum cochinchinense; 5-O-methylcelebixanthone; cytotoxic activity; antimalarial activity
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.54.745

A new prenylated xanthone, 5-O-methylcelebixanthone (1), together with six known compounds; celebixanthone (2), 1,3,7-trihydroxy-2,4-di(3-methylbut-2-enyl)xanthone (3), cochinchinone A (4), α-mangostin (5), β-mangostin (6) and cochinchinone C (7) were isolated from roots of Cratoxylum cochinchinense. Their structures were elucidated by spectroscopic methods. Compounds 2 and 4—7 showed cytotoxic activity against the human lung cancer cell line (NCI-H187) with IC50 values ranging from 0.65 to 5.2 μg/ml. Compounds 1, 2, 6 and 7 also showed antimalarial activity against Plasmodium falciparum with IC50 values of 3.2, 4.9, 7.2 and 2.6 μg/ml, respectively.