Functions of PARylation in DNA Damage Repair Pathways

• Published in: Genomics, proteomics & bioinformatics Vol. 14; no. 3; pp. 131 - 139
• Main Authors: Wei, Huiting, Yu, Xiaochun
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.06.2016; Department of Immunology, Tianjin Key Laboratory of Cellular and Molecular Immunology, M0E Key Laboratory of Immune Microenvironment and Disease, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China%Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA; Elsevier; Oxford University Press
• Subjects: Animals; Chromatin Assembly and Disassembly; DNA - metabolism; DNA Damage; DNA damage response; DNA Repair; DNA修复; DNA损伤修复; Homologous Recombination; Humans; PAR-binding modules; PARP; PARPs; Poly Adenosine Diphosphate Ribose - metabolism; Poly ADP-ribosylation; Poly(ADP-ribose) Polymerases - metabolism; Protein Processing, Post-Translational; Review; Ubiquitination; 生物学作用; 生物过程; 翻译后修饰; 转录调控; 通路; Poly ADP-ribosylation; PAR-binding modules; PARPs; Ubiquitination; DNA damage response
• ISSN: 1672-0229; 2210-3244
• DOI: 10.1016/j.gpb.2016.05.001

Protein poly ADP-ribosylation（PARylation） is a widespread post-translational modification at DNA lesions,which is catalyzed by poly（ADP-ribose） polymerases（PARPs）.This modification regulates a number of biological processes including chromatin reorganization,DNA damage response（DDR）,transcriptional regulation,apoptosis,and mitosis.PARP1,functioning as a DNA damage sensor,can be activated by DNA lesions,forming PAR chains that serve as a docking platform for DNA repair factors with high biochemical complexity.Here,we highlight molecular insights into PARylation recognition,the expanding role of PARylation in DDR pathways,and the functional interaction between PARylation and ubiquitination,which will offer us a better understanding of the biological roles of this unique post-translational modification.