Inhibitory Effects of Triterpenes Isolated from Chuling (Polyporus umbellatus FRIES) on Free Radical-Induced Lysis of Red Blood Cells

• Published in: Biological & Pharmaceutical Bulletin Vol. 28; no. 5; pp. 817 - 821
• Main Authors: Sekiya, Nobuyasu, Hikiami, Hiroaki, Nakai, Yoichiro, Sakakibara, Iwao, Nozaki, Kazuya, Kouta, Kazufumi, Shimada, Yutaka, Terasawa, Katsutoshi
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.05.2005; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: anti-oxidative activity; Chuling; Dose-Response Relationship, Drug; Erythrocytes - drug effects; Erythrocytes - metabolism; Free Radical Scavengers - isolation & purification; Free Radical Scavengers - pharmacology; Free Radicals - antagonists & inhibitors; Free Radicals - pharmacology; hemolysis; Hemolysis - drug effects; Hemolysis - physiology; Humans; Male; Polyporales - isolation & purification; Polyporus umbellatus; triterpene; Triterpenes - isolation & purification; Triterpenes - pharmacology

Chuling, sclerotia of Polyporus umbellatus FRIES, has long been used for urological disorders in traditional medicine. In this study, we demonstrated that Chuling in vitro protects red blood cells from 2,2-azo-bis(2-amidinopropane)dihydrochloride (AAPH)-induced hemolysis. The inhibitory effect was d...