Sleep disturbances and dementia risk: A multicenter study

• Published in: Alzheimer's & dementia Vol. 14; no. 10; pp. 1235 - 1242
• Main Authors: Sindi, Shireen, Kåreholt, Ingemar, Johansson, Lena, Skoog, Johan, Sjöberg, Linnea, Wang, Hui-Xin, Johansson, Boo, Fratiglioni, Laura, Soininen, Hilkka, Solomon, Alina, Skoog, Ingmar, Kivipelto, Miia
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2018
• Subjects: alzheimers-disease; cognitive decline; daytime sleepiness; Dementia; deprivation; disorders; duration; Geriatrics; Geriatrik; health; heart-disease; incident; Insomnia; Medicin och hälsovetenskap; Neurosciences & Neurology; self-reported sleep; Sleep disturbances; Sleep duration; Insomnia; Sleep disturbances; Sleep duration; Dementia
• ISSN: 1552-5260; 1552-5279; 1552-5279
• DOI: 10.1016/j.jalz.2018.05.012

Few longitudinal studies assessed whether sleep disturbances are associated with dementia risk. Sleep disturbances were assessed in three population-based studies (H70 study and Kungsholmen Project [Sweden]; Cardiovascular Risk Factors, Aging and Dementia study [Finland]). Late-life baseline analyses (3–10 years follow-up) used all three studies (N = 1446). Baseline ages ≈ 70 years (Cardiovascular Risk Factors, Aging and Dementia, H70), and ≈84 years (Kungsholmen Project). Midlife baseline (age ≈ 50 years) analyses used Cardiovascular Risk Factors, Aging and Dementia (21 and 32 years follow-up) (N = 1407). Midlife insomnia (fully adjusted hazard ratio = 1.24, 95% confidence interval = 1.02–1.50) and late-life terminal insomnia (fully adjusted odds ratio = 1.94, 95% confidence interval = 1.08–3.49) were associated with a higher dementia risk. Late-life long sleep duration (>9 hours) was also associated with an increased dementia risk (adjusted odds ratio = 3.98, 95% confidence interval = 1.87–8.48). Midlife insomnia and late-life terminal insomnia or long sleep duration were associated with a higher late-life dementia risk.