Antioxidative Flavanone Glycosides from the Branches and Leaves of Viscum coloratum

• Published in: Chemical & Pharmaceutical Bulletin Vol. 54; no. 1; pp. 133 - 135
• Main Authors: Yao, Hui, Liao, Zhi-Xin, Wu, Qiong, Lei, Guang-Qing, Liu, Zhi-Jun, Chen, Dao-Feng, Chen, Jia-Kuan, Zhou, Tong-Shui
• Format: Journal Article
• Language: English; Japanese
• Published: TOKYO The Pharmaceutical Society of Japan 2006; Pharmaceutical Society of Japan; Pharmaceutical Soc Japan; Japan Science and Technology Agency
• Subjects: Antioxidants - chemistry; Antioxidants - isolation & purification; antioxidative activity; Carbohydrate Conformation; Carbohydrate Sequence; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; flavanone glycoside; Flavanones - chemistry; Flavanones - isolation & purification; Free Radical Scavengers - chemistry; Free Radical Scavengers - isolation & purification; Glucosides - chemistry; Glucosides - isolation & purification; Hydroxyl Radical - chemistry; Life Sciences & Biomedicine; Loranthaceae; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oxidants - chemistry; Pharmacology & Pharmacy; Physical Sciences; Plant Extracts - analysis; Plant Leaves - chemistry; Science & Technology; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Superoxides - chemistry; Viscum - chemistry; Viscum coloratum; Xanthine Oxidase - chemistry; Viscum coloratum; antioxidative activity; flavanone glycoside; Loranthaceae
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.54.133

Two new flavanone glucosides, (2S)-homoeriodictyol 7,4′-di-O-β-D-glucopyranoside (4) and (2R)-eriodictyol 7,4′-di-O-β-D-glucopyranoside (5) were isolated from the branches and leaves of Viscum coloratum (KOMAR) NAKAI (Loranthaceae), along with three known flavanone glucosides: (2S)-homoeriodictyol 7-O-β-D-glucopyranoside (1), (2S)-eriodictyol 7-O-β-D-glucopyranoside (2), and (2S)-naringenin 7-O-β-D-glucopyranoside (3). The structures of these compounds were elucidated using spectroscopic methods. The antioxidant activities of these isolated compounds were evaluated by colorimetric methods based on their scavenging effects on hydroxyl radicals and superoxide anion radicals, respectively. All the compounds showed potent albeit varied degrees of antioxidative activities and the structure–activity relationship is discussed.