Longevity-associated mitochondrial DNA 5178 C/A polymorphism modifies effect of aging on renal function in male Japanese health checkup examinees: an exploratory cross-sectional study

• Published in: Journal of physiological anthropology Vol. 38; no. 1; p. 12
• Main Authors: Ohtsu, Iichiro, Ishikawa, Mamoru, Matsunaga, Naomi, Karita, Kanae, Yoshida, Masao, Ochiai, Hirotaka, Shirasawa, Takako, Yoshimoto, Takahiko, Minoura, Akira, Sai, Shogo, Kokaze, Akatsuki
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.09.2019; BioMed Central; BMC
• Subjects: Adult; Aged; Aging; Aging (Biology); Asian Continental Ancestry Group - genetics; Asian Continental Ancestry Group - statistics & numerical data; Cross-Sectional Studies; DNA; DNA, Mitochondrial - genetics; Drinking (Alcoholic beverages); Epidermal growth factor receptors; Estimated glomerular filtration rate; Genetic polymorphisms; Genotyping; Glomerular filtration rate; Glomerular Filtration Rate - physiology; Health; Humans; Japan - epidemiology; Kidney function; Longevity; Longevity - genetics; Male; Middle Aged; Mitochondrial DNA; Mitochondrial DNA polymorphism; NADH dehydrogenase; Original; Physiological aging; Physiological aspects; Physiology; Polymorphism; Polymorphism, Single Nucleotide - genetics; Regression analysis; Renal function; Smoking; Japan; NADH dehydrogenase; Longevity; Physiological aging; Estimated glomerular filtration rate; Kidney function; Mitochondrial DNA polymorphism
• ISSN: 1880-6805; 1880-6791; 1880-6805
• DOI: 10.1186/s40101-019-0204-3

Mitochondrial DNA 5178 (Mt5178) C/A polymorphism is reportedly associated with longevity in the Japanese population. The objective of this study was to investigate whether Mt5178 C/A polymorphism influences the effect of physiological aging on renal function in male Japanese health checkup examinees. A total of 404 male subjects (mean age ± SD, 53.9 ± 7.8 years; range, 29-76 years) were selected from among individuals visiting the hospital for regular medical checkups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effects of Mt5178 C/A polymorphism and aging on renal function was then conducted. Renal function was evaluated by estimated glomerular filtration rate (eGFR). Subjects were divided into three age groups (< 50, 50-59, ≥ 60 years). In simple linear regression analysis, a significant negative association between aging and eGFR was observed in both Mt5178C and Mt5178A genotypic men (P < 0.001 and P = 0.003, respectively). However, in multiple linear regression analysis, a significant effect of aging on reduced eGFR was observed only in Mt5178C genotypic men (P < 0.001). Logistic regression analysis showed that, in the case of reduced eGFR defined as < 75 mL/min/1.73 m , reduced eGFR was dependent on aging in both Mt5178C and Mt5178A genotypic men (P for trend < 0.001 and P for trend = 0.002, respectively). After adjusting for smoking status and alcohol consumption, reduced eGFR was also dependent on aging in both Mt5178C and Mt5178A genotypic men (P for trend < 0.001 and P for trend = 0.014, respectively). However, in reduced eGFR defined as < 90 mL/min/1.73 m , reduced eGFR was dependent on aging only in Mt5178C genotypic men (P for trend < 0.001). This cross-sectional study suggests that Mt5178 C/A polymorphism modulates the effects of physiological aging on kidney function in Japanese men.