Tumor-on-a-chip model for advancement of anti-cancer nano drug delivery system

• Published in: Journal of nanobiotechnology Vol. 20; no. 1; pp. 1 - 338
• Main Authors: Tian, Chutong, Zheng, Shunzhe, Liu, Xinying, Kamei, Ken-ichiro
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 20.07.2022; BioMed Central; BMC
• Subjects: Antimitotic agents; Antineoplastic agents; Cancer therapies; Cell culture; Clinical trials; Dosage and administration; Drug delivery; Drug delivery process; Drug delivery systems; Drugs; Efficiency; Integrated circuits; Metastasis; Microfluidic device; Microfluidics; Nanomedicine; Nanomedicines; Nanoparticles; Nanotechnology; Pharmaceutical research; Physiology; Preclinical prediction; Review; Semiconductor chips; Shear stress; Tissue culture; Tumor microenvironment; Tumor-on-a-Chip; Tumors; Vehicles; China
• ISSN: 1477-3155; 1477-3155
• DOI: 10.1186/s12951-022-01552-0

Despite explosive growth in the development of nano-drug delivery systems (NDDS) targeting tumors in the last few decades, clinical translation rates are low owing to the lack of efficient models for evaluating and predicting responses. Microfluidics-based tumor-on-a-chip (TOC) systems provide a promising approach to address these challenges. The integrated engineered platforms can recapitulate complex in vivo tumor features at a microscale level, such as the tumor microenvironment, three-dimensional tissue structure, and dynamic culture conditions, thus improving the correlation between results derived from preclinical and clinical trials in evaluating anticancer nanomedicines. The specific focus of this review is to describe recent advances in TOCs for the evaluation of nanomedicine, categorized into six sections based on the drug delivery process: circulation behavior after infusion, endothelial and matrix barriers, tumor uptake, therapeutic efficacy, safety, and resistance. We also discuss current issues and future directions for an end-use perspective of TOCs.