Two New Xanthones Isolated from the Stem Bark of Garcinia lancilimba

• Published in: Chemical & Pharmaceutical Bulletin Vol. 55; no. 6; pp. 950 - 952
• Main Authors: Yang, Nian-Yun, Han, Quan-Bin, Cao, Xin-Wei, Qiao, Chun-Feng, Song, Jing-Zheng, Chen, Shi-Lin, Yang, Da-Jian, Yiu, Hillary, Xu, Hong-Xi
• Format: Journal Article
• Language: English
• Published: TOKYO The Pharmaceutical Society of Japan 01.06.2007; Pharmaceutical Society of Japan; Pharmaceutical Soc Japan; Japan Science and Technology Agency
• Subjects: Cell Line, Tumor; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; cytotoxicity; Garcinia - chemistry; Garcinia lancilimba; Guttiferae; Humans; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Pharmacology & Pharmacy; Physical Sciences; Plant Stems - chemistry; Science & Technology; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; xanthone; Xanthones - chemistry; Xanthones - isolation & purification; Xanthones - pharmacology; Garcinia lancilimba; GAMBOGIC ACID; Guttiferae; HANBURYI; PRENYLATED XANTHONES; EPIMERS; cytotoxicity; xanthone
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.55.950

Two new xanthones, 1,5,6-trihydroxy-6′,6′-dimethyl-2H-pyrano(2′,3′:3,4)-2-(3-methylbut-2-enyl)xanthone (1) and 1,6,7-trihydroxy-6′,6′-dimethyl-2H-pyrano(2′,3′:3,2)-4-(3-methylbut-2-enyl)xanthone (2), have been isolated from the stem bark of Garcinia lancilimba (Guttiferae), together with six known xanthones. Their structures were identified on the basis of extensive spectral evidence including detailed 2D NMR and HR-MS data. Two new compounds showed moderate inhibitory effect on human breast cancer MDA-MB-435S cell line.