Zygotic gene activation in mice: profile and regulation

The zygotic genome is transcriptionally silent immediately after fertilization. In mice, initial activation of the zygotic genome occurs in the middle of the one-cell stage. At the mid-to-late two-cell stage, a burst of gene activation occurs after the second round of DNA replication, and the profil...

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Bibliographic Details
Published inJournal of Reproduction and Development Vol. 68; no. 2; pp. 79 - 84
Main Author AOKI, Fugaku
Format Journal Article
LanguageEnglish
Published Japan The Society for Reproduction and Development 01.01.2022
Japan Science and Technology Agency
Subjects
Animals
Chromatin structure
DNA biosynthesis
DNA Replication
Embryonic Development - genetics
Epigenetic factors
Fertilization
Gene expression
Gene Expression Regulation, Developmental
Gene regulation
Genome
Genomes
Kinases
Mice
Preimplantation development
SRD Outstanding Research Award 2021
Transcription
Transcriptional Activation
Zygote - metabolism
Zygotic gene activation
Epigenetic factors
Zygotic gene activation
Preimplantation development
Chromatin structure
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Summary:The zygotic genome is transcriptionally silent immediately after fertilization. In mice, initial activation of the zygotic genome occurs in the middle of the one-cell stage. At the mid-to-late two-cell stage, a burst of gene activation occurs after the second round of DNA replication, and the profile of transcribed genes changes dramatically. These two phases of gene activation are called minor and major zygotic gene activation (ZGA), respectively. As they mark the beginning of the gene expression program, it is important to elucidate gene expression regulation during these stages. This article reviews the outcomes of studies that have clarified the profiles and regulatory mechanisms of ZGA.
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ISSN:0916-8818
1348-4400
DOI:10.1262/jrd.2021-129