Association Between Chemotherapy-Induced Peripheral Neuropathy and Low Anterior Resection Syndrome

Introduction: Low anterior resection syndrome (LARS) can be a debilitating condition that develops after undergoing sphincter-preserving surgery for rectal cancer. Chemotherapy-induced peripheral neuropathy is a common side effect of platinum-based chemotherapy agents used as systemic therapy for re...

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Published inCancers Vol. 16; no. 21; p. 3578
Main Authors Linhares, Samantha M., Schultz, Kurt S., Coppersmith, Nathan A., Esposito, Andrew C., Leeds, Ira L., Pantel, Haddon J., Reddy, Vikram B., Mongiu, Anne K.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 23.10.2024
Subjects
Cancer therapies
Chemotherapy
Colorectal cancer
Ostomy
Patients
Peripheral neuropathy
Quality of life
Questionnaires
Rectum
Regression analysis
Risk factors
Surgery
Surgical anastomosis
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Summary:Introduction: Low anterior resection syndrome (LARS) can be a debilitating condition that develops after undergoing sphincter-preserving surgery for rectal cancer. Chemotherapy-induced peripheral neuropathy is a common side effect of platinum-based chemotherapy agents used as systemic therapy for rectal cancer treatment. The purpose of this study was to determine the potential relationship between CIPN and LARS. Methods: This was a retrospective review of patients who underwent a low anterior resection for rectal cancer and received systemic therapy contacted at least six months from the most recent surgery. Eligible patients were called and completed the relevant surveys over the phone or email. Results: There was a total of 42 patients who completed the surveys with 33 (79%) having major LARS. Presence of a diverting ileostomy was the only significantly differentcharacteristic in those with major LARS versus those without. CIPN was independently associated with LARS (p = 0.046) on linear regression when controlling for neoadjuvant chemoradiation, diverting ileostomy and tumor distance from the anal verge. Conclusions: Developing severe CIPN is associated with developing LARS. Further studies evaluating the etiology behind this relationship should be conducted.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers16213578