Fluctuating plasma phosphorus level by changes in dietary phosphorus intake induces endothelial dysfunction

• Published in: Journal of Clinical Biochemistry and Nutrition Vol. 56; no. 1; pp. 35 - 42
• Main Authors: Watari, Eriko, Taketani, Yutaka, Kitamura, Tomoyo, Tanaka, Terumi, Ohminami, Hirokazu, Abuduli, Maerjianghan, Harada, Nagakatsu, Yamanaka-Okumura, Hisami, Yamamoto, Hironori, Takeda, Eiji
• Format: Journal Article
• Language: English
• Published: Japan SOCIETY FOR FREE RADICAL RESEARCH JAPAN 01.01.2015; Japan Science and Technology Agency; the Society for Free Radical Research Japan
• Subjects: circadian rhythm; dietary phosphorus; inflammation; Original; oxidative stress; phosphorus spike; dietary phosphorus; phosphorus spike; inflammation; oxidative stress; circadian rhythm
• ISSN: 0912-0009; 1880-5086
• DOI: 10.3164/jcbn.14-96

High serum phosphorus (P) impairs endothelial function by increasing oxidative stress and decreasing nitric oxide production. Serum P levels fluctuate due to circadian rhythms or dietary P intake in healthy people and due to dialysis in end-stage chronic kidney disease patients. Here we examined whether fluctuating plasma P caused by changes in dietary P intake may be involved in endothelial dysfunction, resulting in increased cardiovascular risk. Rats were fed a diet containing 0.6% P for 16 days (control group), or a diet alternating between 0.02% P and 1.2% P (LH group) or between 1.2% P and 0.02% P (HL group) every 2 days; the total amount of P intake among the groups during the feeding period was similar. In the LH and HL groups, endothelial-dependent vasodilation significantly decreased plasma 8-(OH)dG level significantly increased, and the expression of inflammatory factors such as MCP-1 increased in the endothelium as compared with the control group. These data indicate that repetitive fluctuations of plasma P caused by varying dietary P intake can impair endothelial function via increased oxidative stress and inflammatory response. Taken together, these results suggest that habitual fluctuation of dietary P intake might be a cause of cardiovascular disease through endothelial dysfunction, especially in chronic kidney disease patients.