Immune Reconstitution in Cord Blood Transplantation

The impact of this immunomodulation can be seen in the various cellular constituents of the immune system. Since there is a Th2 bias, activated maternal T cells may be removed by Fas ligand expression by the human syncytiotrophoblasts (i.e. via apoptosis) [7] at the feto-maternal junction [8]. In CB...

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Bibliographic Details
Published inInternational journal of clinical reviews
Main Authors Tulpule, Sameer, Shaw, Bronwen E
Format Journal Article
LanguageEnglish
Published London Remedica Medical Education and Publishing 15.08.2012
Subjects
Immune system
Immunology
Lymphocytes
Stem cells
Transplants & implants
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Summary:The impact of this immunomodulation can be seen in the various cellular constituents of the immune system. Since there is a Th2 bias, activated maternal T cells may be removed by Fas ligand expression by the human syncytiotrophoblasts (i.e. via apoptosis) [7] at the feto-maternal junction [8]. In CB, there is impaired APC function of CB dendritic cells (DCs), giving rise to low IL-12 expression and reduced Th1 cell responses [10,11]. [...]there is reduced capacity of CB mononuclear cells to secrete cytokines and lymphokines including granulocyte-macrophage colony-stimulating factor (GM-CSF), M-CSF, IL-4, IL-8, IL-12, IL-15, and IL-18 [12,13]. [...]occurring Tregs are produced by the thymus and expression of FOXP3 is thought to be essential for their suppressive functions.
ISSN:2044-3323
2044-3323
DOI:10.5275/ijcr.2012.08.04