Linkage mapping of the mouse nephrosis (nep) gene to chromosome 15

ICGN is a partially inbred strain of mice with nephrotic syndrome caused by spontaneous glomerular lesion. It has been reported that the albuminuria in ICGN mouse was controlled by at least a single autosomal recessive gene (nep). In this study, we mapped the nep locus by linkage analysis of backcro...

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Published inJournal of Veterinary Medical Science Vol. 63; no. 12; pp. 1347 - 1350
Main Authors Okamoto, M. (Osaka Univ., Suita (Japan)), Yokoi, N, Serikawa, T, Tajima, M, Kurosawa, T
Format Journal Article
LanguageEnglish
Published Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.12.2001
Japan Science and Technology Agency
Subjects
Animals
Chromosome Mapping
Crosses, Genetic
DNA - chemistry
DNA - genetics
Female
GENES
GENETIC MAPS
ICGN mouse
KIDNEY DISEASES
linkage mapping
Male
MICE
Mice, Inbred ICR - genetics
nephrosis
Nephrotic Syndrome - genetics
Polymerase Chain Reaction
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Summary:ICGN is a partially inbred strain of mice with nephrotic syndrome caused by spontaneous glomerular lesion. It has been reported that the albuminuria in ICGN mouse was controlled by at least a single autosomal recessive gene (nep). In this study, we mapped the nep locus by linkage analysis of backcross progeny between ICGN and MSM mice using DNA pooling method. The linkage analysis revealed that the nep locus was localized on the distal part of chromosome 15.
Bibliography:L70
2002003663
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.63.1347