Correlated responses of respiratory disease and immune capacity traits of Landrace pigs selected for Mycoplasmal pneumonia of swine (MPS) lesion

• Published in: Animal science journal Vol. 87; no. 9; pp. 1099 - 1105
• Main Authors: Okamura, Toshihiro, Maeda, Kouki, Onodera, Wataru, Kadowaki, Hiroshi, Kojima-Shibata, Chihiro, Suzuki, Eisaku, Uenishi, Hirohide, Satoh, Masahiro, Suzuki, Keiichi
• Format: Journal Article
• Language: English
• Published: Australia Blackwell Publishing Ltd 01.09.2016
• Subjects: Animal diseases; Animals; Antibodies; Antibody Formation - genetics; Antibody Formation - immunology; Body weight; Cortisol; Erythrocytes; Erythrocytes - immunology; genetic parameter; genetic trend; Genetics; Hogs; Hydrocortisone - blood; immunity; Immunology; Leukocytes; Leukocytes - immunology; Livestock; Livestock breeding; Lungs; Lymphocytes; Lymphocytes - immunology; Peripheral blood; Phagocytes; Phagocytosis - genetics; Phagocytosis - immunology; pig; Pneumonia; Pneumonia of Swine, Mycoplasmal - genetics; Pneumonia of Swine, Mycoplasmal - immunology; Quantitative Trait, Heritable; respiratory disease; Respiratory diseases; Respiratory Tract Diseases - genetics; Respiratory Tract Diseases - immunology; Respiratory Tract Diseases - veterinary; Sheep; Suidae; Swine; Swine - genetics; Swine - immunology; Swine Diseases - genetics; Swine Diseases - immunology; Weaning; genetic trend; immunity; genetic parameter; respiratory disease; pig
• ISSN: 1344-3941; 1740-0929
• DOI: 10.1111/asj.12560

Five generations of Landrace pigs selected for average daily gain, backfat thickness, Mycoplasmal pneumonia of swine (MPS) lesion score, and plasma cortisol levels, was executed to decrease the MPS lesion score. Genetic parameters and correlated genetic responses for respiratory disease and peripheral blood immune traits were estimated in 1395 Landrace pigs. We estimated the negative genetic correlation of MPS lesion score with phagocytic activity (PA) at 7 weeks of age (‐0.67). The breeding values of PA at 7 weeks of age and 105 kg body weight and the correlated selection response of the ratio of granular leukocytes to lymphocytes at 105 kg body weight were significantly increased, and sheep red blood cell‐specific antibody production (AP) was significantly decreased in a selection‐dependent manner. Increasing of natural immunological indicators (e.g. PA) and decreasing of humoral immunological indicator (e.g. AP) were observed due to genetically decreasing MPS lesion score.