Hyperglycemia-Induced Reactive Oxygen Species Toxicity to Endothelial Cells Is Dependent on Paracrine Mediators

• Published in: Diabetes (New York, N.Y.) Vol. 57; no. 7; pp. 1952 - 1965
• Main Authors: Busik, Julia V., Mohr, Susanne, Grant, Maria B.
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.07.2008
• Subjects: Annexin A5 - metabolism; Biological and medical sciences; Caspases - metabolism; Cell culture; Cell Culture Techniques; Cell death; Chronic illnesses; Complications; Cytokines; Cytokines - pharmacology; Development and progression; Diabetes; Diabetes. Impaired glucose tolerance; Diabetic retinopathy; Diabetic Retinopathy - etiology; Diabetic Retinopathy - physiopathology; Electromagnetic Phenomena; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Glucose; Glucose - metabolism; Humans; Hyperglycemia; Hyperglycemia - complications; Hyperglycemia - physiopathology; Kinases; Medical sciences; Mitochondria; Mitochondria - metabolism; Oxidative Stress; Phosphorylation; Physiological aspects; Pigment Epithelium of Eye - cytology; Pigment Epithelium of Eye - drug effects; Pigment Epithelium of Eye - metabolism; Proteins; Reactive Oxygen Species - metabolism; Reactive Oxygen Species - toxicity; Research design; Risk factors; Superoxides - metabolism; Toxicity; Tumor necrosis factor-TNF; Vascular Cell Adhesion Molecule-1 - genetics; Canada; Endocrinopathy; Endothelial cell; Hyperglycemia; Oxygen; Toxicity; Diabetes mellitus

Hyperglycemia-Induced Reactive Oxygen Species Toxicity to Endothelial Cells Is Dependent on Paracrine Mediators Julia V. Busik 1 , Susanne Mohr 2 and Maria B. Grant 3 1 Department of Physiology, Michigan State University, East Lansing, Michigan 2 Department of Medicine, Case Western Reserve Universi...