Application of the Next-Generation Sequencing Technology to Reveal Mechanism of Small Cell Lung Cancer Transformation from Adenocarcinoma

To the Editor: Small cell lung cancer (SCLC) transformation is one of the most common mechanisms of resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in non-SCLC (NSCLC). [1] In this study, we performed next-generation sequencing (NGS) with a panel of 168 tumor ge...

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Bibliographic Details
Published inChinese medical journal Vol. 131; no. 9; pp. 1124 - 1125
Main Authors Zhou, Yong-Zhao, Jin, Jing, Tian, Pan-Wen, Li, Wei-Min
Format Journal Article
LanguageEnglish
Published China Wolters Kluwer India Pvt. Ltd 05.05.2018
Medknow Publications and Media Pvt. Ltd
Lippincott Williams & Wilkins Ovid Technologies
Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
Medknow Publications & Media Pvt Ltd
Wolters Kluwer
Subjects
Adenocarcinoma - genetics
Adenocarcinoma - pathology
Biopsy
Cell Transformation, Neoplastic
Consent
Correspondence
Critical care
High-Throughput Nucleotide Sequencing
Humans
Lung cancer
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Medicine
Mutation
Small Cell Lung Carcinoma - genetics
Small Cell Lung Carcinoma - pathology
China
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Summary:To the Editor: Small cell lung cancer (SCLC) transformation is one of the most common mechanisms of resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in non-SCLC (NSCLC). [1] In this study, we performed next-generation sequencing (NGS) with a panel of 168 tumor genes for consecutive repeat biopsy tissue samples of a lung adenocarcinoma patient harboring EGFR exon 19 deletion (ex19del). In a nonsmoking 26-year-old female patient with chest pain, computed tomography (CT) scan revealed a right lung mass and pleural effusion.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0366-6999
2542-5641
DOI:10.4103/0366-6999.230720