A reduction in chronic hepatitis B virus infection prevalence among children in Vietnam demonstrates the importance of vaccination

• Published in: Vaccine Vol. 32; no. 2; pp. 217 - 222
• Main Authors: Nguyen, Tran Hien, Vu, Minh Huong, Nguyen, Van Cuong, Nguyen, Lien Huong, Toda, Kohei, Nguyen, Tuyet Nga, Dao, Sang, Wannemuehler, Kathleen A, Hennessey, Karen A
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 03.01.2014; Elsevier; Elsevier Limited
• Subjects: Allergy and Immunology; Applied microbiology; Biological and medical sciences; Birth dose vaccination; Caregivers; Child; Children & youth; Confidence intervals; Cross-Sectional Studies; Ethnicity; Female; Fundamental and applied biological sciences. Psychology; Health facilities; Hepatitis; Hepatitis B Surface Antigens - blood; Hepatitis B Vaccines - therapeutic use; Hepatitis B virus; Hepatitis B, Chronic - epidemiology; Hepatitis B, Chronic - prevention & control; Human viral diseases; Humans; Immunization; Immunization Programs; Immunization, Secondary; Infections; Infectious diseases; Male; Medical sciences; Microbiology; Miscellaneous; Population density; Prevalence; Sample size; Seroprevalence; Stratigraphy; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vietnam - epidemiology; Viral diseases; Viral hepatitis; Virology; Asia; South east Asia; Vietnam; Birth dose vaccination; Immunization; Hepatitis B virus; Seroprevalence; Human; Prevalence; Tropical zone; Vaccination; Orthohepadnavirus; Hepatic disease; Serology; Vaccine; Epidemiology; Infection; Virus; Viral hepatitis B; Hepadnaviridae; Viral disease; Digestive diseases; Child
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2013.11.004

Highlights • This nationally representative cross-sectional survey sampled children based on a stratified three-stage cluster design. • A total of 6,949 children were included in the survey analyses. • The overall HBsAg prevalence among surveyed children was 2.70%. • Unadjusted HBsAg prevalence among children with ≥3 doses of hepatitis B vaccine including a birth dose (1.75%) was significantly lower than among children with ≥3 doses of hepatitis B vaccine but lacked a birth dose (2.98%). • Childhood chronic HBV infection prevalence has been markedly reduced in Vietnam due to vaccination.