Effect of Omeprazole on Delayed Healing of Acetic Acid-Induced Gastric Ulcers in Rats

Omeprazole, a gastric mucosal proton pump inhibitor, significantly and dose-dependently prevented the delayed healing of acetic acid-induced gastric ulcers in response to repeatedly administered indomethacin to rats. Both basal and histamine-stimulated gastric acid secretions in rats with acetic aci...

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Bibliographic Details
Published inJapanese Journal of Pharmacology Vol. 54; no. 1; pp. 82 - 85
Main Authors Ying WANG, Jian, NAGAI, Hitoshi, OKABE, Susumu
Format Journal Article
LanguageEnglish
Japanese
Published Kyoto The Japanese Pharmacological Society 1990
Japanese Pharmacological Society
Subjects
Acetates
Acetic Acid
Animals
Biological and medical sciences
Digestive system
Drug Therapy, Combination
Gastric Acid - metabolism
Histamine - pharmacology
Indomethacin - administration & dosage
Indomethacin - pharmacology
Male
Medical sciences
Omeprazole - pharmacology
Pharmacology. Drug treatments
Rats
Stomach Ulcer - chemically induced
Stomach Ulcer - drug therapy
Time Factors
Wound Healing - drug effects
Chemotherapy
Experimental disease
Treatment
Animal
Enzyme inhibitor
Ulcer
Antiulcer agent
Cicatrization
Dose activity relation
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Summary:Omeprazole, a gastric mucosal proton pump inhibitor, significantly and dose-dependently prevented the delayed healing of acetic acid-induced gastric ulcers in response to repeatedly administered indomethacin to rats. Both basal and histamine-stimulated gastric acid secretions in rats with acetic acid-induced ulcers that were given indomethacin were markedly and persistently (>24 hr) inhibited after 4 weeks treatment with omeprazole. The prevention of delayed ulcer healing by omeprazole appears to be due to its long-lasting antisecretory activity.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.54.82