In vivo remineralising effect of GC Tooth Mousse on early dental enamel lesions: SEM analysis

• Published in: International dental journal Vol. 61; no. 4; pp. 210 - 216
• Main Authors: Ferrazzano, Gianmaria F., Amato, Ivana, Cantile, Tiziana, Sangianantoni, Giancarla, Ingenito, Aniello
• Format: Journal Article
• Language: English
• Published: Oxford, UK Elsevier Ltd 01.08.2011; Blackwell Publishing Ltd; FDI World Dental Federation; Elsevier Limited; Elsevier
• Subjects: Adolescent; Bioactive peptides; Biological and medical sciences; caries; Cariostatic Agents - pharmacology; Cariostatic Agents - therapeutic use; casein phosphopeptides; Caseins - pharmacology; Caseins - therapeutic use; Child; Dental Caries - drug therapy; Dental Enamel - drug effects; Dental Enamel - ultrastructure; Dentistry; Enamel; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Female; GC Tooth Mousse; Humans; Male; Medical sciences; Microscopy, Electron, Scanning; Non tumoral diseases; Original; Otorhinolaryngology. Stomatology; prevention; Tooth Remineralization - methods; GC Tooth Mousse; casein phosphopeptides; Bioactive peptides; prevention; caries; Scanning electron microscopy; Peptides; Teeth; Dentistry; Prevention; Tooth enamel; In vivo; Early; Tooth; Lesion
• ISSN: 0020-6539; 1875-595X
• DOI: 10.1111/j.1875-595X.2011.00059.x

Objective: Casein phosphopeptide-amorphous calcium phosphate nanocomplexes (CPP-ACP) exhibit anticariogenic potential in laboratory, animal and human experiments. The remineralising potential of synthetic CPPs on early enamel caries was investigated. Design:In vivo study. Setting: University of Naples ‘Federico II’, School of Dentistry, Department of Paediatric Dentistry, 2010, Italy. Participants: 40 volunteers (age range 10–16 years) were recruited and divided in two groups of 20 (Group A and B). Interventions: In Group A subjects two demineralised enamel specimens were placed on the buccal surfaces of the first molars and subjects were instructed to apply a commercial product containing CPPs (GC Tooth Mousse) only on the right-sided specimen and a placebo mousse on the left, for 1 month. In Group B subjects two enamel specimens were similarly placed into the mouth and used as controls. Results: SEM analysis revealed a diffuse and homogeneous mineral coating, reducing the surface alterations only in the demineralised specimens treated with synthetic CPPs into the mouth. Conclusions: Results demonstrate that CPPs are able to promote remineralisation of early enamel lesions.