Hierarchical Fabrication of Engineered Vascularized Bone Biphasic Constructs via Dual 3D Bioprinting: Integrating Regional Bioactive Factors into Architectural Design

• Published in: Advanced healthcare materials Vol. 5; no. 17; pp. 2174 - 2181
• Main Authors: Cui, Haitao, Zhu, Wei, Nowicki, Margaret, Zhou, Xuan, Khademhosseini, Ali, Zhang, Lijie Grace
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 01.09.2016; Wiley Subscription Services, Inc
• Subjects: Biocompatibility; Bioengineering; Bone and Bones - blood supply; Bone and Bones - cytology; Bone and Bones - metabolism; Bones; Chemical reactions; click reaction; Design engineering; dual 3D bioprinting; Health care; Human Umbilical Vein Endothelial Cells - cytology; Human Umbilical Vein Endothelial Cells - metabolism; Humans; mussel-inspired chemistry; Platforms; Printing, Three-Dimensional; regional immobilization; Three dimensional printing; Tissue Engineering; vascularized complex tissue; dual 3D bioprinting; regional immobilization; vascularized complex tissue; click reaction; mussel-inspired chemistry

A biphasic artificial vascularized bone construct with regional bioactive factors is presented using dual 3D bioprinting platform technique, thereby forming a large functional bone grafts with organized vascular networks. Biocompatible mussel‐inspired chemistry and “thiol‐ene” click reaction are use...