Hierarchical Fabrication of Engineered Vascularized Bone Biphasic Constructs via Dual 3D Bioprinting: Integrating Regional Bioactive Factors into Architectural Design

A biphasic artificial vascularized bone construct with regional bioactive factors is presented using dual 3D bioprinting platform technique, thereby forming a large functional bone grafts with organized vascular networks. Biocompatible mussel‐inspired chemistry and “thiol‐ene” click reaction are use...

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Published in	Advanced healthcare materials Vol. 5; no. 17; pp. 2174 - 2181
Main Authors	Cui, Haitao, Zhu, Wei, Nowicki, Margaret, Zhou, Xuan, Khademhosseini, Ali, Zhang, Lijie Grace
Format	Journal Article
Language	English
Published	Germany Blackwell Publishing Ltd 01.09.2016 Wiley Subscription Services, Inc
Subjects	Biocompatibility Bioengineering Bone and Bones - blood supply Bone and Bones - cytology Bone and Bones - metabolism Bones Chemical reactions click reaction Design engineering dual 3D bioprinting Health care Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - metabolism Humans mussel-inspired chemistry Platforms Printing, Three-Dimensional regional immobilization Three dimensional printing Tissue Engineering vascularized complex tissue dual 3D bioprinting regional immobilization vascularized complex tissue click reaction mussel-inspired chemistry
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Abstract	A biphasic artificial vascularized bone construct with regional bioactive factors is presented using dual 3D bioprinting platform technique, thereby forming a large functional bone grafts with organized vascular networks. Biocompatible mussel‐inspired chemistry and “thiol‐ene” click reaction are used to regionally immobilize bioactive factors during construct fabrication for modulating or improving cellular events.
AbstractList	A biphasic artificial vascularized bone construct with regional bioactive factors is presented using dual 3D bioprinting platform technique, thereby forming a large functional bone grafts with organized vascular networks. Biocompatible mussel-inspired chemistry and "thiol-ene" click reaction are used to regionally immobilize bioactive factors during construct fabrication for modulating or improving cellular events. A biphasic artificial vascularized bone construct with regional bioactive factors is presented using dual 3D bioprinting platform technique, thereby forming a large functional bone grafts with organized vascular networks. Biocompatible mussel-inspired chemistry and "thiol-ene" click reaction are used to regionally immobilize bioactive factors during construct fabrication for modulating or improving cellular events.A biphasic artificial vascularized bone construct with regional bioactive factors is presented using dual 3D bioprinting platform technique, thereby forming a large functional bone grafts with organized vascular networks. Biocompatible mussel-inspired chemistry and "thiol-ene" click reaction are used to regionally immobilize bioactive factors during construct fabrication for modulating or improving cellular events.
Author	Cui, Haitao Zhang, Lijie Grace Zhu, Wei Nowicki, Margaret Zhou, Xuan Khademhosseini, Ali
Author_xml	– sequence: 1 givenname: Haitao surname: Cui fullname: Cui, Haitao organization: Department of Mechanical and Aerospace Engineering, The George Washington University, 3590 Science and Engineering Hall 800 22nd Street NW, DC, 20052, Washington, USA – sequence: 2 givenname: Wei surname: Zhu fullname: Zhu, Wei organization: Department of Mechanical and Aerospace Engineering, The George Washington University, 3590 Science and Engineering Hall 800 22nd Street NW, DC, 20052, Washington, USA – sequence: 3 givenname: Margaret surname: Nowicki fullname: Nowicki, Margaret organization: Department of Mechanical and Aerospace Engineering, The George Washington University, 3590 Science and Engineering Hall 800 22nd Street NW, DC, 20052, Washington, USA – sequence: 4 givenname: Xuan surname: Zhou fullname: Zhou, Xuan organization: Department of Mechanical and Aerospace Engineering, The George Washington University, 3590 Science and Engineering Hall 800 22nd Street NW, DC, 20052, Washington, USA – sequence: 5 givenname: Ali surname: Khademhosseini fullname: Khademhosseini, Ali organization: Harvard-MIT Division of Health Sciences and Technology, Wyss Institute for Biologically Inspired Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, MA, 02139, Cambridge, USA – sequence: 6 givenname: Lijie Grace surname: Zhang fullname: Zhang, Lijie Grace email: lgzhang@gwu.edu, lgzhang@gwu.edu organization: Department of Mechanical and Aerospace Engineering, The George Washington University, 3590 Science and Engineering Hall 800 22nd Street NW, 20052, Washington, DC, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/27383032$$D View this record in MEDLINE/PubMed
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Snippet	A biphasic artificial vascularized bone construct with regional bioactive factors is presented using dual 3D bioprinting platform technique, thereby forming a...
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SubjectTerms	Biocompatibility Bioengineering Bone and Bones - blood supply Bone and Bones - cytology Bone and Bones - metabolism Bones Chemical reactions click reaction Design engineering dual 3D bioprinting Health care Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - metabolism Humans mussel-inspired chemistry Platforms Printing, Three-Dimensional regional immobilization Three dimensional printing Tissue Engineering vascularized complex tissue
Title	Hierarchical Fabrication of Engineered Vascularized Bone Biphasic Constructs via Dual 3D Bioprinting: Integrating Regional Bioactive Factors into Architectural Design
URI	https://api.istex.fr/ark:/67375/WNG-N7S2PV5L-S/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fadhm.201600505 https://www.ncbi.nlm.nih.gov/pubmed/27383032 https://www.proquest.com/docview/1817077387 https://www.proquest.com/docview/1817838475 https://www.proquest.com/docview/1827908319 https://www.proquest.com/docview/1835627012 https://pubmed.ncbi.nlm.nih.gov/PMC5014673
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