Minimum Alveolar Concentration for Blunting Adrenergic Responses (MAC-BAR) of Sevoflurane in Dogs

It is well known that heart rate or arterial blood pressure may increase in response to surgical stimulation despite the absence of a purposeful movement. However, there is limited information regarding anesthetic requirement for blunting adrenergic response in dogs. This study was designed to compa...

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Published in	Journal of Veterinary Medical Science Vol. 74; no. 4; pp. 507 - 511
Main Authors	YAMASHITA, Kazuto, FURUKAWA, Erika, ITAMI, Takaharu, ISHIZUKA, Tomohito, TAMURA, Jun, MIYOSHI, Kenjirou
Format	Journal Article
Language	English
Published	Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.04.2012 Japan Science and Technology Agency
Subjects	anesthesia Anesthetics, Inhalation - administration & dosage Animals Autonomic Nervous System - drug effects Blood Gas Analysis - veterinary Blood Pressure - drug effects Body Temperature - drug effects canine Dogs - metabolism Dogs - surgery Female Heart Rate - drug effects MAC-BAR Methyl Ethers - administration & dosage Pulmonary Alveoli - drug effects Pulmonary Alveoli - metabolism Sevoflurane
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Abstract	It is well known that heart rate or arterial blood pressure may increase in response to surgical stimulation despite the absence of a purposeful movement. However, there is limited information regarding anesthetic requirement for blunting adrenergic response in dogs. This study was designed to compare the minimum alveolar concentrations of sevoflurane required to prevent autonomic response (MAC-BAR) and purposeful movement (MAC) in dogs. Sevoflurane MAC-BAR and MAC were determined in 5 beagle dogs by judging dogs' response to a noxious electrical stimulus applied to the gingiva. The sevoflurane MAC-BAR was significantly higher than MAC (3.33 ± 0.48 vs 2.10 ± 0.28%, P=0.005). These results suggested that autonomic responses occurred at sevoflurane anesthetic concentrations at which purposeful movements were absent.
AbstractList	It is well known that heart rate or arterial blood pressure may increase in response to surgical stimulation despite the absence of a purposeful movement. However, there is limited information regarding anesthetic requirement for blunting adrenergic response in dogs. This study was designed to compare the minimum alveolar concentrations of sevoflurane required to prevent autonomic response (MAC-BAR) and purposeful movement (MAC) in dogs. Sevoflurane MAC-BAR and MAC were determined in 5 beagle dogs by judging dogs' response to a noxious electrical stimulus applied to the gingiva. The sevoflurane MAC-BAR was significantly higher than MAC (3.33 ± 0.48 vs 2.10 ± 0.28%, P=0.005). These results suggested that autonomic responses occurred at sevoflurane anesthetic concentrations at which purposeful movements were absent.
Author	ITAMI, Takaharu YAMASHITA, Kazuto MIYOSHI, Kenjirou TAMURA, Jun ISHIZUKA, Tomohito FURUKAWA, Erika
Author_xml	– sequence: 1 fullname: YAMASHITA, Kazuto organization: Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido 069-8501, Japan – sequence: 2 fullname: FURUKAWA, Erika organization: Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido 069-8501, Japan – sequence: 3 fullname: ITAMI, Takaharu organization: Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido 069-8501, Japan – sequence: 4 fullname: ISHIZUKA, Tomohito organization: Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido 069-8501, Japan – sequence: 5 fullname: TAMURA, Jun organization: Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido 069-8501, Japan – sequence: 6 fullname: MIYOSHI, Kenjirou organization: Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido 069-8501, Japan
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SubjectTerms	anesthesia Anesthetics, Inhalation - administration & dosage Animals Autonomic Nervous System - drug effects Blood Gas Analysis - veterinary Blood Pressure - drug effects Body Temperature - drug effects canine Dogs - metabolism Dogs - surgery Female Heart Rate - drug effects MAC-BAR Methyl Ethers - administration & dosage Pulmonary Alveoli - drug effects Pulmonary Alveoli - metabolism Sevoflurane
Title	Minimum Alveolar Concentration for Blunting Adrenergic Responses (MAC-BAR) of Sevoflurane in Dogs
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