Minimum Alveolar Concentration for Blunting Adrenergic Responses (MAC-BAR) of Sevoflurane in Dogs

• Published in: Journal of Veterinary Medical Science Vol. 74; no. 4; pp. 507 - 511
• Main Authors: YAMASHITA, Kazuto, FURUKAWA, Erika, ITAMI, Takaharu, ISHIZUKA, Tomohito, TAMURA, Jun, MIYOSHI, Kenjirou
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.04.2012; Japan Science and Technology Agency
• Subjects: anesthesia; Anesthetics, Inhalation - administration & dosage; Animals; Autonomic Nervous System - drug effects; Blood Gas Analysis - veterinary; Blood Pressure - drug effects; Body Temperature - drug effects; canine; Dogs - metabolism; Dogs - surgery; Female; Heart Rate - drug effects; MAC-BAR; Methyl Ethers - administration & dosage; Pulmonary Alveoli - drug effects; Pulmonary Alveoli - metabolism; Sevoflurane
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.11-0274

It is well known that heart rate or arterial blood pressure may increase in response to surgical stimulation despite the absence of a purposeful movement. However, there is limited information regarding anesthetic requirement for blunting adrenergic response in dogs. This study was designed to compare the minimum alveolar concentrations of sevoflurane required to prevent autonomic response (MAC-BAR) and purposeful movement (MAC) in dogs. Sevoflurane MAC-BAR and MAC were determined in 5 beagle dogs by judging dogs' response to a noxious electrical stimulus applied to the gingiva. The sevoflurane MAC-BAR was significantly higher than MAC (3.33 ± 0.48 vs 2.10 ± 0.28%, P=0.005). These results suggested that autonomic responses occurred at sevoflurane anesthetic concentrations at which purposeful movements were absent.