Inhibitory Effect of Ellagitannin Metabolites on IgE-Mediated Allergic Responses in RBL-2H3 Cells

• Published in: Bioscience, biotechnology, and biochemistry Vol. 76; no. 12; pp. 2310 - 2312
• Main Authors: NAGANO, Takao, ITO, Hideyuki, OKAMOTO, Takeaki
• Format: Journal Article
• Language: English
• Published: Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 2012; Japan Society for Bioscience Biotechnology and Agrochemistry; Oxford University Press
• Subjects: allergy; Animals; Biological and medical sciences; Cell Line, Tumor; Degranulation; ellagitannin; Fundamental and applied biological sciences. Psychology; Hydrolyzable Tannins - metabolism; Hydrolyzable Tannins - pharmacology; Hypersensitivity - immunology; Hypersensitivity - metabolism; Hypersensitivity - prevention & control; immunoglobulin E; Immunoglobulin E - immunology; Interleukin-4 - secretion; Mast Cells - drug effects; Mast Cells - immunology; Mast Cells - secretion; metabolites; rat basophilic leukemia-2H3 cells; Rats; Tumor Necrosis Factor-alpha - secretion; Allergy; Immunoglobulins; Rat; Basophilic leukemia; Metabolite; IgE; Rodentia; immunoglobulin E; metabolites; ellagitannin; Vertebrata; Mammalia; rat basophilic leukemia-2H3 cells; Inhibitor; Tumor cell
• ISSN: 0916-8451; 1347-6947
• DOI: 10.1271/bbb.120448

The effects of four ellagitannin metabolites (M1-M4) and ellagic acid on immunoglobulin E-mediated allergic responses in rat basophilic leukemia-2H3 cells were investigated. M1-M4 inhibited the antigen-induced degranulation and secretion of interleukin-4 and tumor necrosis factor-α, but ellagic acid only slightly did so under the same experimental conditions. M1 inhibited the activation of the mitogen-activated protein kinases in antigen-stimulated cells.