Induction of pluripotency by defined factors

The “reversion of cell fate from differentiated states back into totipotent or pluripotent states” has been an interest of many scientists for a long time. With the help of knowledge accumulated by those scientists, we succeeded in converting somatic cells to a pluripotent cell lineage by the forced...

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Bibliographic Details
Published inProceedings of the Japan Academy, Series B Vol. 90; no. 3; pp. 83 - 96
Main Authors TANABE, Koji, TAKAHASHI, Kazutoshi, YAMANAKA, Shinya
Format Journal Article
LanguageEnglish
Published Japan The Japan Academy 2014
Subjects
Animals
Cellular biology
Cellular Reprogramming - drug effects
Drug Discovery
Gene expression
Humans
Induced Pluripotent Stem Cells - cytology
Induced Pluripotent Stem Cells - drug effects
Induced Pluripotent Stem Cells - metabolism
iPS cell
pluripotent
Proteins
Regenerative Medicine
reprogramming
Review
Stem cells
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Summary:The “reversion of cell fate from differentiated states back into totipotent or pluripotent states” has been an interest of many scientists for a long time. With the help of knowledge accumulated by those scientists, we succeeded in converting somatic cells to a pluripotent cell lineage by the forced expression of defined factors. These established induced pluripotent stem (iPS) cells have similar features to embryonic stem (ES) cells, including pluripotency and immortality. The iPS cell technology provides unprecedented opportunities for regenerative medicine and drug discovery.
Bibliography:Contributed by Shinya YAMANAKA, M.J.A.
ISSN:0386-2208
1349-2896
DOI:10.2183/pjab.90.83