Acute phase response in naturally occurring coliform mastitis

• Published in: Journal of Veterinary Medical Science Vol. 63; no. 6; pp. 675 - 678
• Main Authors: Ohtsuka, H. (Kitasato Univ., Towada, Aomori (Japan). Coll. of Veterinary and Animal Sciences), Kudo, K, Mori, K, Nagai, F, Hatsugaya, A, Tajima, M, Tamura, K, Hoshi, F, Koiwa, M, Kawamura, S
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.06.2001; Japan Science and Technology Agency
• Subjects: ACUTE COURSE; acute phase protein; Acute-Phase Proteins - analysis; Acute-Phase Proteins - biosynthesis; Acute-Phase Reaction - immunology; Acute-Phase Reaction - microbiology; Acute-Phase Reaction - veterinary; Animals; Body Temperature; CATTLE; coliform mastitis; cytokine; CYTOKINES; Cytokines - biosynthesis; Cytokines - blood; DAIRY COWS; Enterobacteriaceae - growth & development; Enterobacteriaceae Infections - immunology; Enterobacteriaceae Infections - microbiology; Enterobacteriaceae Infections - veterinary; ESCHERICHIA COLI; Female; Haptoglobins - analysis; Haptoglobins - biosynthesis; Leukocyte Count - veterinary; MASTITIS; Mastitis, Bovine - immunology; Mastitis, Bovine - microbiology; Orosomucoid - analysis; Orosomucoid - biosynthesis; Platelet Count - veterinary; Pulse - veterinary
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.63.675

Changes in the activities of serum cytokines and in acute phase response were observed in dairy cows with naturally occurring coliform mastitis. Seven cows with severe mastitis showed systemic and mammary inflammatory response throughout the observation period, and 11 cows with mild mastitis recovered and were able to be milked within 3 days of onset of mastitis. Serum interleukin (IL)-1 and tumor necrosis factor (TNF) activities were higher in the severe group than in the mild group at the first appearance of symptoms. Elevated IL-1 activity was evident in the severe group throughout the observation period. Serum alpha-1-acidglycoprotein (alpha1AG) concen-tration began to rise with the beginning of mastitis in the severe group, and peaked at 9 days. Serum haptoglobin (Hp) concentrations peaked at 3 days, and decreased gradually after 3 days in the severe group. These results showed that there are dynamic changes in serum IL-1 activity and in serum alpha1AG and Hp concentrations in cows with severe coliform mastitis.