Accelerating Effect of Soy Peptides Containing Collagen Peptides on Type I and III Collagen Levels in Rat Skin

• Published in: Bioscience, biotechnology, and biochemistry Vol. 76; no. 8; pp. 1549 - 1551
• Main Authors: INOUE, Yoshiki, ITOH, Hitomi, AOKI, Marie, OGAWA, Sachie, YAMANE, Takumi, BABA, Toshimitsu, TACHIBANA, Nobuhiko, KOHNO, Mitsutaka, OISHI, Yuichi, KOBAYASHI-HATTORI, Kazuo
• Format: Journal Article
• Language: English
• Published: Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 2012; Japan Society for Bioscience Biotechnology and Agrochemistry; Oxford University Press
• Subjects: Administration, Oral; Animals; Biological and medical sciences; collagen peptide; Collagen Type I - biosynthesis; Collagen Type III - biosynthesis; Diet; Fundamental and applied biological sciences. Psychology; Gene Expression - drug effects; Glucuronosyltransferase - genetics; Glucuronosyltransferase - metabolism; Hyaluronan Synthases; Hydroxymethylglutaryl CoA Reductases - genetics; Hydroxymethylglutaryl CoA Reductases - metabolism; Male; Peptides - administration & dosage; Rats; Rats, Wistar; RNA, Messenger - biosynthesis; Serine C-Palmitoyltransferase - genetics; Serine C-Palmitoyltransferase - metabolism; Skin - drug effects; Skin - metabolism; soy peptide; Soybean Proteins - administration & dosage; tropocollagen; Tropocollagen - biosynthesis; Vertebrata; Mammalia; Collagen type I; Peptides; Rat; Rodentia; soy peptide; Skin; collagen peptide; tropocollagen
• ISSN: 0916-8451; 1347-6947
• DOI: 10.1271/bbb.120088

Two weeks of feeding soy peptides containing 2% collagen peptides increased the levels of type I and III tropocollagen and their mRNAs. In contrast, the diet did not increase the mRNA levels of rat hyaluronan synthases, serine palmitoyltransferase (the rate-limiting enzyme of ceramide synthesis), and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (the key enzyme of cholesterol synthesis). These results suggest that feeding of soy peptides with collagen peptides specifically enhanced the tropocollagen level in the skin.