Roles for SUMO in pre-mRNA processing

When the small ubiquitin-like modifier (SUMO)-1 protein is localized on the genome, it is found on proteins bound to the promoters of the most highly active genes and on proteins bound to the DNA-encoding exons. Inhibition of the SUMO-1 modification leads to reductions in initiation of messenger RNA...

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Bibliographic Details
Published inWiley interdisciplinary reviews. RNA Vol. 7; no. 1; p. 105
Main Authors Nuro-Gyina, Patrick K, Parvin, Jeffrey D
Format Journal Article
LanguageEnglish
Published United States 01.01.2016
Subjects
Cysteine Endopeptidases - genetics
Cysteine Endopeptidases - metabolism
Genome
Humans
Polyadenylation
RNA Precursors - metabolism
RNA Splicing
RNA, Messenger - metabolism
Transcriptome
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Summary:When the small ubiquitin-like modifier (SUMO)-1 protein is localized on the genome, it is found on proteins bound to the promoters of the most highly active genes and on proteins bound to the DNA-encoding exons. Inhibition of the SUMO-1 modification leads to reductions in initiation of messenger RNA (mRNA) synthesis and splicing. In this review, we discuss what is known about the SUMOylation of factors involved in transcription initiation, pre-mRNA processing, and polyadenylation. We suggest a mechanism by which SUMO modifications of factors at the promoters of high-activity genes trigger the formation of an RNA polymerase II complex that coordinates and integrates the stimulatory signals for each process to catalyze an extremely high level of gene expression. WIREs RNA 2016, 7:105-112. doi: 10.1002/wrna.1318 For further resources related to this article, please visit the WIREs website.
ISSN:1757-7012
DOI:10.1002/wrna.1318