AD dementia risk in late MCI, in early MCI, and in subjective memory impairment

• Published in: Alzheimer's & dementia Vol. 10; no. 1; pp. 76 - 83
• Main Authors: Jessen, Frank, Wolfsgruber, Steffen, Wiese, Birgitt, Bickel, Horst, Mösch, Edelgard, Kaduszkiewicz, Hanna, Pentzek, Michael, Riedel-Heller, Steffi G, Luck, Tobias, Fuchs, Angela, Weyerer, Siegfried, Werle, Jochen, van den Bussche, Hendrik, Scherer, Martin, Maier, Wolfgang, Wagner, Michael
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2014; ALZHEIMER'S & DEMENTIA
• Subjects: Aged; Aged, 80 and over; Ageing; Alzheimer Disease - diagnosis; Alzheimer Disease - epidemiology; Alzheimer Disease - mortality; Alzheimer Disease - psychology; Alzheimer's disease; Alzheimer's disease dementia; Apolipoprotein E4 - genetics; At risk; Cognitive Dysfunction - diagnosis; Cognitive Dysfunction - epidemiology; Cognitive Dysfunction - mortality; Cohort analysis; Cohort Studies; Female; Humans; Male; Memory; Memory Disorders - diagnosis; Memory Disorders - epidemiology; Mild cognitive impairment; Neurology; Neuropsychological Tests; Primary health care; Prospective cohort study; Psychiatric Status Rating Scales; Risk; Subjective memory impairment; Survival Analysis; Risk; Alzheimer's disease dementia; Mild cognitive impairment; Prospective cohort study; Subjective memory impairment
• ISSN: 1552-5260; 1552-5279; 1552-5279
• DOI: 10.1016/j.jalz.2012.09.017

Abstract Objective To compare the risk of developing Alzheimer’s disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance. Methods The baseline sample (n = 2892) of the prospective cohort study in nondemented individuals (German Study on Aging, Cognition and Dementia in Primary Care Patients) was divided into LMCI, EMCI, SMI, and control subjects by delayed recall performance. These groups were subdivided by the presence of self-reported concerns associated with experienced memory impairment. AD dementia risk was assessed over 6 years. Results Across all groups, risk of AD dementia was greatest in LMCI. In those with self-reported concerns regarding their memory impairment, SMI and EMCI were associated with a similarly increased risk of AD dementia. In those subgroups without concerns, SMI was not associated with increased risk of AD dementia, but EMCI remained an at-risk condition. Conclusions SMI and EMCI with self-reported concerns were associated with the same risk of AD dementia, suggesting that pre-LMCI risk conditions should be extended to SMI with concerns.