Publication bias - Importance of studies with negative results

There are three reasons for negative results: studies with small sample size and lacking power, no difference between groups, and more complications or adverse events in the study group. [...]due to publication bias, the final analysis does not involve negative data as it has either not been publish...

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Bibliographic Details
Published inIndian journal of anaesthesia Vol. 63; no. 6; pp. 505 - 507
Main Author Nair, Abhijit
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer India Pvt. Ltd 01.06.2019
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer - Medknow
Wolters Kluwer Medknow Publications
Subjects
Bias
Letters to Editor
Meta-analysis
Researchers
Studies
Systematic review
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Summary:There are three reasons for negative results: studies with small sample size and lacking power, no difference between groups, and more complications or adverse events in the study group. [...]due to publication bias, the final analysis does not involve negative data as it has either not been published ever or has been rejected. [...]the practice guidelines that evolve from the results of systematic reviews and meta-analyses which comes under the category of level 1 evidence has to be taken into consideration with a pinch of salt. [...]the editorial board should insist authors on submitting negative results also which should be considered for publication if found suitable based on appropriate methods, statistical methods used and acceptable discussion.
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ISSN:0019-5049
0976-2817
DOI:10.4103/ija.IJA_142_19